JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (1): 22-25.doi: 10.6040/j.issn.1671-7554.0.2016.1332

Previous Articles     Next Articles

Strategies for infertility treatment in elderly women

SHI Yuhua, LI Jing   

  1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics;
    Key Laboratory of Reproductive Endocrinology(Shandong University), Ministry of Education;
    Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan 250001, Shandong, China
  • Received:2016-10-18 Online:2017-01-10 Published:2017-01-10

PDF (PC)

321

Abstract: Women older than 35 years of age should be counseled about age-related fertility decline and high risk of pregnancy complications if they have the desire of fertility. After failed attempts to conceive, in vitro fertilization(IVF), assisted reproductive techniques and adjunct agents may be adopted, including recombinant luteinizing hormone(r-LH), growth hormone(GH), coenzyme Q10(CoQ10), and dehydroepiandrosterone(DHEA). Change of life style may increase live birth rate. Oocyte donation may be the most effective assisted reproductive strategy.

Key words: Infertility, In vitro fertilization, Assisted reproductive technology, Elderly women

CLC Number: 

  • R711.6
[1] American College of Obstetricians and Gynecologists Committee on Gynecologic Practice and Practice Committee. Female age-related fertility decline. Committee Opinion No. 589[J]. Fertil Steril, 2014, 101(3): 633-634.
[2] Toner JP, Coddington CC, Doody K, et al. Society for Assisted Reproductive Technology and assisted reproductive technology in the United States: a 2016 update[J]. Fertil Steril, 2016, 106(3): 541-546.
[3] Liu K, Case A, Cheung AP, et al. Advanced reproductive age and fertility[J]. J Obstet Gynaecol Can, 2011, 33(11): 1165-1175.
[4] Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile female: a committee opinion[J]. Fertil Steril, 2015, 103(6): e44-50.
[5] 中华医学会妇产科学分会产科学组. 孕前和孕期保健指南(第1版)[J]. 中华妇产科杂志, 2011, 46(2): 150-153.
[6] Wennberg AL, Opdahl S, Bergh C, et al. Effect of maternal age on maternal and neonatal outcomes after assisted reproductive technology[J]. Fertil Steril, 2016, 106(5): 1142-1149.e14.
[7] Tsafrir A, Simon A, Margalioth EJ, et al. What should be the first-line treatment for unexplained infertility in women over 40 years of age-ovulation induction and IUI, or IVF?[J]. Reprod Biomed Online, 2009, 19(Suppl 4): 47-56.
[8] Goldman MB, Thornton KL, Ryley D, et al. A randomized clinical trial to determine optimal infertility treatment in older couples: the forty and over treatment trial(FORT-T)[J]. Fertil Steril, 2014, 101(6): 1574-1581 e1-2.
[9] Lazer T, Dar S, Shlush E, et al. Comparison of IVF outcomes between minimal stimulation and high-dose stimulation for patients with poor ovarian reserve[J]. Int J Reprod Med, 2014, 2014: 581451. doi: 10.1155/2014/581451.
[10] Wong PC, Qiao J, Ho C, et al. Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy: an Asian perspective[J]. Reprod Biomed Online, 2011, 23(1): 81-90.
[11] Duffy JM, Ahmad G, Mohiyiddeen L, et al. Growth hormone for in vitro fertilization[J]. Cochrane Database Syst Rev, 2010,(1): CD000099. doi: 10.1002/14651858.CD000099.pub3.
[12] Yu X, Ruan J, He LP, et al. Efficacy of growth hormone supplementation with gonadotrophins in vitro fertilization for poor ovarian responders: an updated meta-analysis[J]. Int J Clin Exp Med, 2015, 8(4): 4954-4967.
[13] Ben-Meir A, Burstein E, Borrego-Alvarez A, et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging[J]. Aging Cell, 2015, 14(5): 887-895.
[14] Ozcan P, Ficicioglu C, Kizilkale O, et al. Can coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage?[J]. J Assist Reprod Genet, 2016, 33(9): 1223-1230.
[15] Bentov Y, Hannam T, Jurisicova A, et al. Coenzyme Q10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment[J]. Clin Med Insights Reprod Health, 2014, 8: 31-36. doi: 10.4137/CMRH.S14681.
[16] Sen A, Prizant H, Light A, et al. Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression[J]. Proc Natl Acad Sci U S A, 2014, 111(8): 3008-3013.
[17] Narkwichean A, Jayaprakasan K, Maalouf WE, et al. Effects of dehydroepiandrosterone on in vivo ovine follicular development[J]. Hum Reprod, 2014, 29(1): 146-154.
[18] Li J, Yuan H, Chen Y, et al. A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection[J]. Int J Gynaecol Obstet, 2015, 131(3): 240-245.
[19] Nagels HE, Rishworth JR, Siristatidis CS, et al. Androgens(dehydroepiandrosterone or testosterone)for women undergoing assisted reproduction[J]. Cochrane Database Syst Rev, 2015(11): CD009749. doi: 10.1002/14651858.CD009749.pub2.
[20] Gat I, Blanco Mejia S, Balakier H, et al. The use of coenzyme Q10 and DHEA during IUI and IVF cycles in patients with decreased ovarian reserve[J]. Gynecol Endocrinol, 2016, 32(7): 534-537.
[21] Reynolds KA, Omurtag KR, Jimenez PT, et al. Cycle cancellation and pregnancy after luteal estradiol priming in women defined as poor responders: a systematic review and meta-analysis[J]. Hum Reprod, 2013, 28(11): 2981-2989.
[22] Buyuk E, Seifer DB, Illions E, et al. Elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve[J]. Fertil Steril, 2011, 95(7): 2364-2368.
[23] Vural F, Vural B, Cakiroglu Y. The role of overweight and obesity in In Vitro Fertilization outcomes of poor ovarian responders[J]. Biomed Res Int, 2015, 2015: 781543. doi: 10.1155/2015/781543.
[24] Selesniemi K, Lee HJ, Muhlhauser A, et al. Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies[J]. Proc Natl Acad Sci U S A, 2011, 108(30): 12319-12324.
[25] Simchen MJ, Yinon Y, Moran O, et al. Pregnancy outcome after age 50[J]. Obstet Gynecol, 2006, 108(5): 1084-1088.
[26] Klitzman RL. How old is too old? Challenges faced by clinicians concerning age cutoffs for patients undergoing in vitro fertilization[J]. Fertil Steril, 2016, 106(1): 216-224.
[27] Oocyte or embryo donation to women of advanced reproductive age: an Ethics Committee opinion[J]. Fertil Steril, 2016, 106(5): e3-e7.
[1] LI Mei. Quality of oocytes and embryos of elder women [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 16-21.
[2] CHEN Zijiang. Clinical concern of the second pregnancy under the two-child policy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 1-4.
[3] DENG Xiaohui, XU Yaxuan. Fertility evaluation and assisted reproduction in elder women [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 5-10.
[4] YANG Dongzi, MAI Zhuoyao. Features of ovarian reserve and outcomes of assisted reproductive technology in elder patients with PCOS [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 26-32.
[5] XI Xianghong, SU Rong, JIA Shaotong, TANG Xiuying, WANG Lixin. Correlation between human epididymis protein 4 in seminal plasma and male infertility [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(5): 66-69.
[6] HA Lingxia, LI Xianghong. Expression and significance of GDF9 and BMP15 in follicular fluid of women with polycysticovary syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(10): 77-80,95.
[7] CHANG Fuli，LI Shuling ， LI Yuzhu
. Kidneybenefiting and conceptionaiding granules in treating infertility due to ovulatory dysfunction [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(02): 82-84.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd