JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (7): 34-38.doi: 10.6040/j.issn.1671-7554.0.2014.933

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Diagnostic value of frozen section for breast intraductal papillary neoplasms

DAI Gaosai, MA Tingting, JIANG Liyu, HUO Qiang, KONG Xiaoli, JING Chuyu, YANG Qifeng   

  1. Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-12-10 Revised:2015-03-13 Online:2015-07-10 Published:2015-07-10

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Abstract: Objective To investigate the significance of intraoperative frozen section in the diagnosis of intraductal papillary neoplasms and influencing factors. Methods Clinical data of 560 patients with intraductal papillary neoplasms confirmed with postoperative paraffin pathology in the Department of Breast Surgery, Qilu Hospital of Shandong University during Jan. 2007 to Dec. 2013 were retrospectively analyzed. The results of intraoperative frozen sections and postoperative paraffin sections were compared and factors affecting diagnostic accuracy rate were studied. Results The overall accuracy rate of intraoperative frozen sections was 85.1%. The accuracy rate of intraductal papilloma and intraductal papillary carcinoma was 88.9% and 49.0%, respectively (P<0.05). Of all patients, 16 cases (3.1%) with higher and 1 case (0.2%) with lower pathological grade were observed. The accuracy rate with and without nipple discharge was 89.2% and 79.4%, respectively (P<0.05). Conclusion Intraoperative frozen section can yield high accuracy for the diagnosis of intraductal papillary neoplasms. The accuracy rate of intraductal papilloma is higher than that of intraductal papillary carcinoma, and the accuracy rate is higher in patients with nipple discharge than those without.

Key words: Intraductal papillary neoplasms, Paraffin section, Frozen section, Nipple discharge

CLC Number: 

  • R655.8
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