JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (11): 92-96.doi: 10.6040/j.issn.1671-7554.0.2014.554

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Genome-wide association study of autism in Shandong Province

YANG Shulin1, YANG Fan2, ZHAI Jing3, LIU Jintong3, ZHANG Yan3, CHEN Gang4   

  1. 1. School of Public Health, Taishan Medical University, Taian 271016, Shandong, China;
    2. Department of Pathology, Affiliated Hospital of Taishan Medical University, Taian 271000, Shandong, China;
    3. Department of Children's Psychological Science, Shandong Mental Health Center, Jinan 250014, Shandong, China;
    4. Laboratory of Genetics, Institute of Basic Medicine, Jinan 250062, Shandong, China
  • Received:2014-08-26 Published:2014-11-10
  • Contact: 陈刚.Email:chengang560515@163.com E-mail:chengang560515@163.com

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Abstract: Objective To investigate the genetic loci associated with autism in the population of Shandong Province. Methods Linkage Mapping Set 2.5 including 400 microsatellite markers was used to screen 3 separated DNA pooling samples consisting of 38 autism children, their 75 parents and 1 000 normal controls. CLUMP and SPSS12.0 software were adopted for statistic analysis to compare the difference in allele frequency of each locus between autism children and controls, autism children and parents respectively. Results Significant differences in allele frequency were found at 1p36.31, 4q13.3, 4q35.1 and 7p21.3. Conclusion Genetic loci 1p36.31, 4q13.3, 4q35.1 and 7p21.3 are detected to be associated with autism in the population of Shandong Province, and susceptibility genes may be located around these regions.

Key words: Genome, Genetics, Autism, DNA pooling

CLC Number: 

  • R749.94
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