血清蛋白质β-折叠水平与冠心病的相关性

doi:10.6040/j.issn.1671-7554.0.2021.1328

摘要/Abstract

摘要： 目的探讨血清β-折叠水平与冠心病的相关性,分析影响β-折叠水平的各种危险因素。方法选取223例冠心病患者(冠心病组)和56例健康查体人群(正常对照组)为研究对象,记录各组临床基本资料,留取外周血标本,采用硫磺素T染色法检测血清β-折叠水平。比较两组基本资料、血清β-折叠水平,多因素Logistic回归分析β-折叠水平与冠心病的相关性。结果冠心病组血清ThT荧光强度明显增加(P<0.05或P<0.01);冠心病组血清β-折叠的水平与腰臀比、年龄、心率、舒张压、糖化血红白蛋白(HbA1c)、低密度脂蛋白胆固醇(LDL-C)、血钠(Na)、白细胞计数和乳酸脱氢酶(LDH)水平呈正相关(P<0.05或P<0.01),也与高血压病史、吸烟史、糖尿病病史、高血脂病史及冠心病家族史呈正相关(P<0.05或P<0.01);血清β-折叠水平、性别、收缩压、甘油三酯(TG)、血糖(Glu)、同型半胱氨酸(Hcy)是冠心病的独立危险因素(P<0.05或P<0.01)。结论冠心病患者中血清β-折叠水平明显升高,是冠心病的独立危险因素,并且血清β-折叠的作用独立于LDL-C。

关键词: β-折叠, 冠心病, 低密度脂蛋白胆固醇, 动脉粥样硬化, 心血管残余风险

Abstract: Objective To investigate the relationship between serum β-sheet level and coronary heart disease(CHD). Methods A total of 223 CHD patients and 56 healthy controls were recruited. Baseline information, coronary lesion-related indicators and peripheral blood samples were collected. Serum protein β-sheet level was determined with thioflavin T fluorescence. The relationship between β-sheet level and CHD was analyzed with multivariate Logistic regression. Results Serum ThT fluorescence intensity increased significantly in CHD group(P<0.05 or P<0.01). The β-sheet level was positively correlated with waist-hip ratio, age, heart rate, diastolic blood pressure, glycosylated hemoglobin(HbA1C), low density lipoprotein cholesterol(LDL-C), sodium(Na), white blood cell(WBC)and lactic dehydrogenase(LDH), as well as with the history of hypertension, smoking, diabetes, hyperlipidemia and family history of CHD(P<0.05 or P<0.01). Serum β-sheet level, sex, systolic blood pressure, triglyceride(TG), glucose(Glu)and homocysteine(Hcy)were independent risk factors for CHD(P<0.05 or P<0.01). Conclusion The serum β-sheet level increases in CHD patients, which is an independent risk factor for CHD, and independent of known risk factors such as LDL-C.

Key words: β-sheet, Coronary heart disease, Low density lipoprotein cholesterol, Atherosclerosis, Residual cardiovascular risk

中图分类号:

R541.4

谢佳莹,祁佳,宋铭,李育林,王迪,贾旭,张薇,钟明,尚嫄嫄. 血清蛋白质β-折叠水平与冠心病的相关性[J]. 山东大学学报 (医学版), 2022, 60(1): 21-26.

XIE Jiaying, QI Jia, SONG Ming, LI Yulin, WANG Di, JIA Xu, ZHANG Wei, ZHONG Ming, SHANG Yuanyuan. Association between serum β-sheet level and coronary heart disease[J]. Journal of Shandong University (Health Sciences), 2022, 60(1): 21-26.

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