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山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (1): 49-54.doi: 10.6040/j.issn.1671-7554.0.2020.1112

• 临床医学 • 上一篇    下一篇

3 514例乳腺癌9年间临床及病理学特征分析

游雪婷1,田兴松1,2   

  1. 1.山东大学附属省立医院乳腺甲状腺外科, 山东 济南 250021;2. 山东第一医科大学附属省立医院乳腺甲状腺外科, 山东 济南 250021
  • 发布日期:2021-01-09
  • 通讯作者: 田兴松. E-mail:txs0509@163.com
  • 基金资助:
    山东省自然科学基金面上项目(ZR2019MH118);济南市科技计划项目(201805011)

Analysis of clinicopathological characteristics of 3 514 cases of breast cancer over 9 years

YOU Xueting1, TIAN Xingsong1,2   

  1. 1. Department of Breast and Thyroid Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong, China;
    2. Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2021-01-09

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摘要： 目的 分析3 514例乳腺癌患者9年间的临床病理学特征。 方法 回顾分析2010年7月至2018年6月就诊于山东大学附属省立医院乳腺甲状腺外科并行手术治疗的乳腺癌患者的临床病理资料,信息来源于病例病案记录,采用相对数及构成比描述分析其临床及病理学特征指标。 结果 3 514例乳腺癌患者性别(男/女)比例为1.00∶318.45,中位发病年龄为50岁,发病高峰年龄为40~50岁,最高峰年龄段为45~50岁。同时性双侧乳腺癌占所有乳腺癌患者的1.05%,多灶性/多中心性乳腺癌占所有乳腺癌患者的5.07%。主要病理类型为浸润性导管癌,其次为导管内癌。9年间乳腺癌患者的病理类型构成比差异有统计学意义(P<0.001)。TNM 0期及Ⅰ期乳腺癌患者的年间构成比差异有统计学意义(P=0.004,P=0.009)。组织学Ⅱ级、Ⅱ~Ⅲ级和Ⅲ级的年间构成比差异有统计学意义(P<0.001)。Luminal A型、Luminal B型及HER-2阳性(HR阴性)型的年间构成比差异均有统计学意义(P<0.001,P<0.001,P=0.032)。乳腺癌伴随乳腺增生病9年间构成比的差异有统计学意义(P=0.047)。9年间肿瘤累及脉管的比例的差异有统计学意义(P=0.018)。9年间乳腺癌患者的淋巴结转移情况差异也有统计学意义(P=0.003)。 结论 研究阐明了3 514例乳腺癌患者的发病年龄、性别比例、病理类型、分子分型、分期等临床及病理特征及其于9年间的变化状况,可为山东省乳腺癌患者的临床病理特征研究提供信息。

关键词: 乳腺肿瘤, 病理特征, 临床特征, 单中心, 年间变化

Abstract: Objective To analyze the clinicopathological characteristics of breast cancer. Methods The clinicopathological data of 3 514 patients who underwent surgery in Department of Breast and Thyroid Surgery of Provincial Hospital Affiliated to Shandong University during July 2010 and June 2018 were retrospectively analyzed. All information was obtained from the medical records. The clinicopathological characteristics were described and analyzed using the relative number and constituent ratio. Results The gender ratio(male/female)was 1.00∶318.45, median age of onset was 50, peak age of onset was 40-50, and the highest peak age was 45-50. Synchronous bilateral and multifocal/multicentric breast cancer accounted for 1.05% and 5.07% of all cases, respectively. The main pathological type was invasive ductal carcinoma, followed by intraductal carcinoma. There were significant differences in the constituent ratio of pathological types(P<0.001); interannual constituent ratio of TNM stage 0 and stage Ⅰ(P=0.004, P=0.009); annual constituent ratio of histological grade Ⅱ,Ⅱ-Ⅲ, and Ⅲ(P<0.001); annual constituent ratio of Luminal A, Luminal B and HER-2 positive(HR negative)types(P<0.001, P<0.001, P=0.032); constituent ratio of breast cancer complicated with hyperplasia of mammary glands(P=0.047); proportion of vascular invasion(P=0.018); and lymph node metastasis(P=0.003). Conclusion The clinicopathological characteristics of 3 514 breast cancer patients, including age of onset, gender ratio, pathological types, molecular classifications and stages over 9 years are elucidated, which can provide reference for the study of clinicopathological characteristics of breast cancer patients in Shandong Province.

Key words: Breast cancer, Pathological characteristics, Clinical features, Monocentric, Inter-annual variation

中图分类号: 

  • R737.9
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