您的位置：山东大学 -> 科技期刊社 -> 《山东大学学报（医学版）》

山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (1): 55-58.doi: 10.6040/j.issn.1671-7554.0.2020.1128

• 临床医学 • 上一篇    下一篇

507例男性生殖道感染病原体分布及耐药特征

赵立红1,赵书平1,聂升刚1,孙晶1,姜同峰2   

  1. 泰安市中心医院 1.检验科;2.皮肤性病科 山东 泰安 271000
  • 发布日期:2021-01-09
  • 通讯作者: 赵书平. E-mail:lihongzhao70@sina.com
  • 基金资助:
    山东省医药卫生科技发展计划资助项目(2017WS175)

Distribution and antimicrobial resistance of multiple pathogens in 507 males with genital tract infections

ZHAO Lihong1, ZHAO Shuping1, NIE Shenggang1, SUN Jing1, JIANG Tongfeng2   

  1. 1. Department of Clinical Laboratory;
    2. Department of Clinical Dermatovenereology, Tai’an City Central Hospital, Taian 271000, Shandong, China
  • Published:2021-01-09

PDF (PC)

213

摘要： 目的 分析泰安市男性生殖道感染患者病原体的分布特点与耐药特征。 方法 选取2016年9月至2018年9月泰安市7家医院泌尿外科、生殖科或性病科男性患者,采集标本,进行病原体培养与药敏试验测定。淋病奈瑟菌采用含万古霉素的巧克力平板进行培养,质谱法进行鉴定,琼脂稀释法进行药敏试验;支原体培养采用肉汤培养法,药敏试验采用肉汤稀释法;衣原体检测采用抗原诊断法。 结果 筛选出507例阳性标本中,单纯解脲脲原体(UU)感染率为39.84%(202/507),单纯淋病奈瑟菌(NG)感染率为23.08%(117/507),多病原体混合感染率为26.43%(134/507)。161株NG对环丙沙星(CIP)、青霉素(PEN)、四环素(TET)的耐药率分别为96.90%、96.27%和96.65%,对头孢曲松(CRO)和头孢克肟(CFM)的低敏率分别为9.32% 和9.94%。UU与人型支原体(MH)对美满霉素(MIN)、强力霉素(DOX)和交沙霉素(JOS)敏感率均在90%以上。 结论 泰安市男性生殖道感染中,主要为单一病原体感染,单纯UU感染居于第1位,其次为单纯NG感染。CRO等第三代头孢菌素仍为泰安市治疗男性淋病的首选药物,MIN、DOX和JOS为泰安市治疗男性生殖道支原体感染的首选药物。

关键词: 男性, 泌尿生殖道, 病原体, 感染, 耐药性, 泰安

Abstract: Objective To analyze the distribution and antimicrobial resistance of multiple pathogens in males with genital tract infections. Methods Multiple pathogens in clinical specimens collected from 7 hospitals in Taian during Sep. 2016 and Sep. 2018 were cultured. Neisseria gonorrhoeae(NG)was cultured on a chocolate tablet containing vancomycin and identified with mass spectrometry, and drug susceptibility was tested with agar dilution method. Ureaplasma urealyticum(UU)was cultured in broth, and drug susceptibility was tested with broth dilution method. Mycoplasma hominis(MH)was tested with IES. Results A total of 507 positive samples were screened out, among which the infection rate of simple UU, simple NG, and multiple pathogens was 39.84%, 23.08%, and 26.43%, respectively. The resistance rate of NG against ciprofloxacin(CIP), penicillin(PEN), and tetracycline(TET)was 96.90%, 96.27%, and 96.65%, respectively. The rate of decreased susceptibility of NG against ceftriaxone(CRO)and cefixime(CFM)was 9.32% and 9.94%, respectively. The susceptibility rates of UU and MH against minocycline(MIN), doxycycline(DOX)and josamycin(JOS)were more than 90%. Conclusion The infection rate of simple UU ranked the first, followed by simple NG. The third-generation cephalosporins such as CRO and CFM remained the first-line therapy for NG infections, and MIN, DOX and JOS were effective antibiotics for UU and MH infections.

Key words: Male, Urogenital tract, Multiple pathogens, Infection, Antimicrobial resistance, Taian

中图分类号: 

  • R446.5
[1] Esen B, Gozalan A, Sevindi DF, et al. Ureaplasma urealyticum: presence among sexually transmitted diseases [J]. Jpn J Infect Dis, 2017, 70(1): 75-79.
[2] 张欠欠, 宋静, 党旭东. 男性患者泌尿生殖道感染病原体荧光定量PCR检测分析[J]. 中华男科学杂志, 2018, 24(3): 282-284.
[3] 曹辉, 夏万宝, 丁夏丽, 等. 上海松江地区性传播疾病病原体感染特点分析[J]. 检验医学, 2019, 34(9): 804-807. CAO Hui, XIA Wanbao, DING Xiali, et al. Analysis of the characteristics of sexually transmitted disease infection in Songjiang District of Shanghai [J]. Laboratory Medicine, 2019, 34(9): 804-807.
[4] 张志红, 张娜, 李小改, 等. 泌尿系感染患者沙眼衣原体与淋病奈瑟菌和解脲脲原体感染及耐药状况调查[J]. 中华医院感染学杂志, 2017, 27(8): 1717-1720. ZHANG Zhihong, ZHANG Na, LI Xiaogai, et al. Investigation of Chlamydia trachomatis, Neisseria gonorrhoeae and Ureaplasma urealyticum infection and drug resistance in patients with urinary tract infection [J]. Chin J Nosocomiol, 2017, 27(8): 1717-1720.
[5] CLSI, Clinical and Laboratory Standard Institute. Performance standards for antimicrobial susceptibility testing: twenty-eighth informational supplement M100-S28[M]. 28th.ed. PA, USA: CLSI Wayne, 2018: 72-74.
[6] World Health Organization(WHO), 2012. Global action plan to control the spread and impact of anti-microbial resistance in Neisseria gonorrhoeae. Geneva: WHO, 2012, 20. Available from: http://apps.who.int/iris/bitstream/10665/44863/1/9789241503501_eng.pdf.
[7] Sonmez C, Usluca S, Hakki Usluca I, et al. Evaluation of symptomatic patients with resistant discharge [J]. Acta Dermatovenerol Croat, 2018, 26(1): 1-7.
[8] 陈晓颖, 陈航, 焦丽丽. 男性生殖道支原体感染特征及耐药分析[J]. 医学理论与实践, 2020, 33(2): 292-293.
[9] Jiang FX, Lan Q, Le WJ, et al. Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Hefei(2014-2015): genetic characteristics of antimicrobial resistance [J]. BMC Infect Dis, 2017, 17(1): 366.
[10] Yan J, Xue J, Chen Y, et al. Increasing prevalence of Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone and resistance to azithromycin in Hangzhou, China(2015-17)[J]. J Antimicrob Chemother, 2019, 74(1): 29-37.
[11] Zhao L, Liu A, Li R, et al. Trends in antimicrobial resistance in Neisseria gonorrhoeae and molecular characteristics of Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone in Shandong, China, 2007 to 2014 [J]. Int J Antimicrob Agents, 2018, 51(1): 52-56.
[12] Kasprzykowska U, Sobieszczańska B, Duda-Madej A, et al. A twelve-year retrospective analysis of prevalence and antimicrobial susceptibility patterns of Ureaplasma spp. and Mycoplasma hominis in the province of Lower Silesia in Poland [J]. Eur J Obstet Gynecol Reprod Biol, 2018, 220: 44-49.
[13] Zhou YH, Ma HX, Yang Y, Gu WM. Prevalence and antimicrobial resistance of Ureaplasma spp. and Mycoplasma hominis isolated from semen samples of infertile men in Shanghai, China from 2011 to 2016 [J]. Eur J Clin Microbiol Infect Dis, 2018, 37(4): 729-734.
[14] 甘红婉, 钟雨. 不同抗菌药物对泌尿生殖道沙眼衣原体感染患者的有效性与安全性比较[J]. 抗感染药学, 2018, 15(10): 1763-1765.
[15] Foschi C, Salvo M, Cevenini R, et al. Chlamydia trachomatis antimicrobial susceptibility in colorectal and endocervical cells [J]. J Antimicrob Chemother, 2018, 73(2): 409-413.
[1] 姚雪,卢冉冉,孙淑玲,高翠平,肖茹,王书会. 风湿性心脏病患者瓣膜置换术后医院感染风险预测评分模型的构建[J]. 山东大学学报 (医学版), 2022, 60(6): 90-96.
[2] 王菊,高帅,范玉琛,王凯. 肝衰竭并发真菌感染综合治疗1例[J]. 山东大学学报 (医学版), 2022, 60(5): 125-128.
[3] 李艳丽,李燕,佘凯丽,刘盈,刘伟娟,李秀君,刘英慧. 山东省部分结核病定点医院护理人员潜伏感染现状及风险因素分析[J]. 山东大学学报 (医学版), 2022, 60(4): 107-112.
[4] 安袁笑雪,杜以明,田甜,张一,薛玉文. 肺炎奴卡菌合并天美奴卡菌肺部感染1例报道并文献复习[J]. 山东大学学报 (医学版), 2022, 60(3): 59-63.
[5] 吕岩红,张志勉. 2 809名体检人群中高血压与幽门螺杆菌感染的关联性[J]. 山东大学学报 (医学版), 2022, 60(2): 43-47.
[6] 王洲洋,江蓓,李宪花,甄军晖,杨向东,胡昭,刘广义,裴斐. 感染性心内膜炎、急性肾损伤伴PR3-ANCA阳性患者1例报道[J]. 山东大学学报 (医学版), 2022, 60(2): 60-64.
[7] 毕凤英,闫冬勤,陈曦,罗丹. HIV感染者/艾滋病患者自杀死亡危险因素理论框架构建——基于扎根理论的定性研究[J]. 山东大学学报 (医学版), 2022, 60(1): 109-117.
[8] 李燕,刘静,李娟,杨秋红. 50例孕产妇血流感染临床特征及胎盘病理分析[J]. 山东大学学报 (医学版), 2022, 60(1): 48-54.
[9] 鞠建华,杨镇业,李青连,韩亚楠,李艳青,乔伊君,杨虎,张华然. 微生物药物研究开发现状与思考[J]. 山东大学学报 (医学版), 2021, 59(9): 43-50,63.
[10] 程晓光,卢艳慧. 男性骨质疏松：一个长期被忽视的问题[J]. 山东大学学报 (医学版), 2021, 59(6): 5-9.
[11] 朱序理,周亮,王跃,孙庆云,曹明雅,杜元杰,曹金凤,赵志明,郝桂敏. 不同精子来源质量冷冻方式与妊娠结局的关联性分析[J]. 山东大学学报 (医学版), 2021, 59(6): 86-93.
[12] 王凤霞,王涛,刘晓. 格氏乳球菌致急性结石性胆囊炎1例[J]. 山东大学学报 (医学版), 2021, 59(6): 122-124.
[13] 林玉玺,李传玺,王霖,马伟. 男男性行为人群性取向告知与艾滋病病毒检测:社会规范与自我效能的链式中介作用[J]. 山东大学学报 (医学版), 2021, 59(3): 113-119.
[14] 黄秀丽,刘丙菊,孙立锋. PIK3CD基因突变致PI3Kδ过度活化综合征1例并文献复习[J]. 山东大学学报 (医学版), 2021, 59(3): 107-112.
[15] 刘雪燕,王光鹏,姚雪,卢冉冉,王书会. 神经外科患者医院感染经济负担和住院时间分析[J]. 山东大学学报 (医学版), 2021, 59(10): 87-93.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 张杰,李振华,孙晋浩,暴丽华,刘岳鹏. 恒定磁场对Schwann细胞氧化损伤的保护作用[J]. 山东大学学报(医学版), 2007, 45(3): 229 -232 .
[2] 郑敏,郝跃伟,刘雪平,赵婷婷. 血小板膜糖蛋白Ibα基因HPA-2、Kozak序列多态性与脑梗死的相关性研究[J]. 山东大学学报(医学版), 2008, 46(3): 292 -295 .
[3] 焦芳芳,刘世青,李飞,李长生,王琴,孙青,鹿伟 . 化瘀理肺方对大鼠肺间质纤维化时Smad7和TGF-β表达的影响[J]. 山东大学学报(医学版), 2007, 45(10): 1054 -1058 .
[4] 赵瑛，颜磊，张辉，于鹏，李明江，赵兴波. 精子相关抗原9在卵巢浆液性上皮肿瘤中的表达[J]. 山东大学学报(医学版), 2012, 50(2): 98 .
[5] 王术芹,齐 峰,吴剑波,孙宝柱. 罗哌卡因对大鼠离体主动脉收缩作用的钙离子调节机制[J]. 山东大学学报(医学版), 2008, 46(8): 773 -776 .
[6] 滕学仁,赵永生,胡光亮,周伦,李建民 . 两种方法保存同种异体髌腱移植重建膝关节交叉韧带的光镜电镜观察[J]. 山东大学学报(医学版), 2008, 46(10): 945 -950 .
[7] 方英立,马玉燕,刘锡梅,周文 . 急诊剖宫产患者围手术期替硝唑合理应用[J]. 山东大学学报(医学版), 2007, 45(10): 995 .
[8] 姜红菊,李润智,王营,徐冬梅,张梅,张运,李继福 . 冠状动脉粥样硬化斑块形态及介入治疗与MMP-9的关系[J]. 山东大学学报(医学版), 2008, 46(10): 966 -970 .
[9] 袁吴敏,赵志伦,王洁贞 . 吸烟和饮酒与颅内肿瘤关系的Meta分析[J]. 山东大学学报(医学版), 2006, 44(11): 1146 -1149 .
[10] 赵鹏,毕万利,李宁 . 螺旋CT后处理技术对青少年先天性脊柱畸形的诊断价值[J]. 山东大学学报(医学版), 2007, 45(8): 825 -829 .
版权所有 © 2018 《山东大学学报(医学版)》编辑部　
地址:山东大学科技期刊社（济南市历城区山大南路27号山东大学中心校区明德楼B座721室） 电话: 0531-88366918 E-mail: xbyxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发