山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (6): 94-99.doi: 10.6040/j.issn.1671-7554.0.2018.1397
• • 上一篇
商蒙蒙1,张岩2,程琳1,孙霄1,时丹丹1,闵香3,李杰1
SHANG Mengmeng1, ZHANG Yan2, CHENG Lin1, SUN Xiao1, SHI Dandan1, MIN Xiang3, LI Jie1
摘要: 目的 比较弹性应变率比值法与声触诊组织量化(VTQ)技术对乳腺肿块的诊断价值。 方法 经手术病理证实的49例女性乳腺疾病患者共计52个乳腺肿块进行压迫式弹性成像和VTQ检查,分别测量肿块与周围正常腺体的应变率比值、肿块内部的剪切波传播速度。构建受试者工作特征(ROC)曲线,分析两种超声弹性成像方法对乳腺肿块的诊断价值,并采用Z检验进行比较。 结果 弹性应变率比值法鉴别乳腺良恶性病变的曲线下面积为0.919,最优诊断界点为0.499,灵敏度、特异度、阳性预测值、阴性预测值、准确率分别为93.6%、72.0%、78.8%、94.7%、84.6%;VTQ技术鉴别诊断乳腺良恶性病变的曲线下面积为0.796,最优诊断界点为2.90 m/s,灵敏度、特异度、阳性预测值、阴性预测值、准确率分别为68.0%、92.6%、89.5%、75.8%、80.8%。两种超声弹性成像方法的ROC曲线下面积比较差异无统计学意义(Z=1.580,P=0.057)。两者联合鉴别诊断乳腺良恶性病变,灵敏度为84.0%,特异度为88.9%,PPV为87.5%,NPV为85.7%,准确率为86.5%。 结论 弹性应变率比值法与VTQ技术能够(半)定量评价乳腺肿块的硬度,两者对乳腺肿块的鉴别诊断价值相近。弹性应变率比值法的灵敏度高于VTQ技术,而特异度却低于VTQ技术。两者联合应用可提高超声鉴别诊断乳腺良恶性病变的灵敏度、特异度和准确率。
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