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山东大学学报(医学版) ›› 2017, Vol. 55 ›› Issue (1): 26-32.doi: 10.6040/j.issn.1671-7554.0.2016.1334

• 高龄生育专题 • 上一篇    下一篇

高龄多囊卵巢综合征患者的卵巢储备特点及其助孕结局

杨冬梓,麦卓瑶   

  1. 中山大学孙逸仙纪念医院妇产科, 广东 广州 510120
  • 收稿日期:2016-10-18 出版日期:2017-01-10 发布日期:2017-01-10
  • 通讯作者: 杨冬梓. E-amil:yangdz@mail.sysu.edu.cn E-mail:-amil:yangdz@mail.sysu.edu.cn
  • 基金资助:
    国家自然科学基金(81370680);广东省自然基金重点项目(2013020012660);广州市科技项目(2014YZ-00512);中山大学5010项目(2014005)

Features of ovarian reserve and outcomes of assisted reproductive technology in elder patients with PCOS

YANG Dongzi, MAI Zhuoyao   

  1. Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong, China
  • Received:2016-10-18 Online:2017-01-10 Published:2017-01-10

摘要: 35岁后多囊卵巢综合征(PCOS)患者的卵巢储备较之同龄人可能有一定的优势。在行辅助生育技术(ART)过程中,40岁前的获卵数往往高于同龄非PCOS人群,40岁以后PCOS患者同样有卵泡质量及胚胎发育潜能不足的问题,对ART助孕结局产生不利影响。现有资料表明,PCOS患者在40岁以后的临床妊娠率、活产率与同龄非PCOS人群的变化趋势一样,同时其代谢、内分泌因素对妊娠结局的负面影响仍然存在。

关键词: 多囊卵巢综合征, 高龄, 妊娠结局, 辅助生殖技术

Abstract: Patients with polycystic ovary syndrome(PCOS)older than 35yrs may possess a potential advantage of ovarian reserve compared with women of the same age. When assisted reproductive technology(ART)is performed, PCOS 山 东 大 学 学 报 (医 学 版)55卷1期 -杨冬梓,等.高龄多囊卵巢综合征患者的卵巢储备特点及其助孕结局 \=-patients younger than 40yrs usually have more retrieved oocytes than age-matched non-PCOS infertile patients. Nevertheless, age related decline in the quality of follicles and deficiency in fetal development adversely affect the outcomes of ART in PCOS patients thereafter. Data show that PCOS patients have the same tendency of age-related decline in terms of clinical pregnancy rate and live birth rate, as with non-PCOS population of the same age, while metabolic and endocrine factors unfavorably influence pregnancy outcomes.

Key words: Assisted reproductive technology, Ageing, Outcome, Polycystic ovary syndrome

中图分类号: 

  • R588
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