山东大学学报 (医学版) ›› 2024, Vol. 62 ›› Issue (5): 89-94.doi: 10.6040/j.issn.1671-7554.0.2024.0212
• 临床医学 • 上一篇
魏闫若雪1,李梓绮1,刘春铖1,刘晓晗1,赵然1,2,刘玉昆1,2
WEI Yanruoxue1, LI Ziqi1, LIU Chuncheng1, LIU Xiaohan1, ZHAO Ran1,2, LIU Yukun1,2
摘要: 目的 探讨结直肠癌(colorectal cancer, CRC)中特异蛋白1(specificity protein 1, SP1)表达的瘤内异质性(intratumor heterogeneity, ITH)及其临床意义。 方法 收集CRC临床标本,采用免疫组化EnVision法检测SP1蛋白的表达水平及模式,明确SP1蛋白表达的ITH特征,定义SP1蛋白的ITH水平,并分析SP1蛋白ITH水平与CRC患者临床病理特征及预后的关系。 结果 在CRC中SP1蛋白呈典型的ITH表达特征,其ITH水平与淋巴结转移(P<0.001)和TNM分期(P<0.001)相关。生存分析表明,SP1蛋白高ITH患者的总生存期(overall survival, OS)显著低于SP1蛋白低ITH患者(61.25% vs 81.82%),差异有统计学意义(P=0.004)。单因素和多因素Cox回归分析显示,SP1蛋白高ITH是CRC患者不良OS(HR=2.680,P=0.017)的独立预测因子。 结论 CRC中SP1蛋白的表达具有显著的ITH特征,并首次定义了SP1 ITH水平的量化标准,证实SP1蛋白高ITH与CRC进展及不良预后显著相关。
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