山东大学学报 (医学版) ›› 2024, Vol. 62 ›› Issue (4): 24-30.doi: 10.6040/j.issn.1671-7554.0.2024.0184
• 临床医学 • 上一篇
刘春铖1,刘晓晗1,魏闫若雪1,李梓绮1,刘玉昆1,2,赵然1,2
LIU Chuncheng1, LIU Xiaohan1, WEI Yanruoxue1, LI Ziqi1, LIU Yukun1,2, ZHAO Ran1,2
摘要: 目的 探讨结直肠癌(colorectal cancer, CRC)中含溴结构域蛋白9(bromodomain containing 9, BRD9)的蛋白表达水平、亚细胞定位模式及其临床意义。 方法 收集CRC手术切除标本,采用免疫组织化学技术EnVision法检测BRD9的蛋白表达水平及其亚细胞定位,并分析其与患者临床病理特征及预后的关系。 结果 在508例CRC组织标本中,BRD9高表达患者为71.46%(363/508),BRD9细胞核阳性患者为80.31%(408/508);BRD9的表达与患者肿瘤大小(P=0.025)、淋巴结转移(P=0.004)、神经侵犯(P=0.043)、分化程度(P=0.017)及TNM分期(P=0.002)相关,BRD9的亚细胞定位与患者淋巴结转移(P=0.040)及TNM分期(P=0.026)相关,差异有统计学意义;BRD9高表达可作为患者的独立不良预后因素(HR=1.994,P=0.002),同时,在BRD9低表达患者中,BRD9细胞浆阳性可作为患者的独立不良预后因素(HR=8.056,P=0.001)。 结论 在CRC患者中BRD9的亚细胞定位模式具有异质性,其高表达及细胞浆定位与CRC的发生发展密切相关,并能够作为独立预测因子预测患者的生存预后。
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