母胎免疫调节机制的研究进展

doi:10.6040/j.issn.1671-7554.0.2021.0794

摘要/Abstract

摘要： 母胎界面在对同种半异体胎儿产生耐受性的同时保持对感染的防御,在生殖学和免疫学引起了广泛关注。母胎界面是正常妊娠建立和维持的关键部位,主要由滋养细胞、蜕膜免疫细胞、蜕膜基质细胞共同组成,对母胎界面免疫机制的深入研究有助于进一步阐明人类妊娠并发症的发病机制。综述总结了近年来母胎免疫的研究成果,围绕母胎界面的关键细胞功能、细胞及细胞因子间相互作用进行说明,旨在此基础上阐述母胎免疫调节机制。

关键词: 母胎界面, 滋养细胞, 蜕膜免疫细胞

Abstract: The maternal-fetal interface develops tolerance to the homohemiallogeneic fetus while maintaining defense against infection, which has aroused great concern in reproduction and immunology. The maternal-fetal interface is a key site for the establishment and maintenance of normal pregnancy, which is composed of trophoblast cells, decidual immune cells and decidual stromal cells. Studies on the immune mechanism of the maternal-fetal interface help to elucidate the pathogenesis of many human pregnancy complications. In this paper, the research achievements of maternal-fetal immunity in recent years are summarized, and the key cellular functions of maternal-fetal interface and the interactions between cells and cytokines are described, aiming to elaborate the mechanism of maternal-fetal immune regulation.

Key words: Maternal-fetal interface, Trophoblast cell, Decidual immune cells

中图分类号:

R714.03

乔宠,王婷婷. 母胎免疫调节机制的研究进展[J]. 山东大学学报 (医学版), 2021, 59(8): 24-31.

QIAO Chong, WANG Tingting. Research progress of maternal-fetal immunomodulatory mechanism[J]. Journal of Shandong University (Health Sciences), 2021, 59(8): 24-31.

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