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山东大学学报 (医学版) ›› 2020, Vol. 58 ›› Issue (2): 79-84.doi: 10.6040/j.issn.1671-7554.0.2019.1070

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原发性纵隔精原细胞瘤1例报告及文献复习

陈荣,李海超,赵健   

  1. 山东大学齐鲁医院胸外科, 山东 济南 250012
  • 出版日期:2020-02-10 发布日期:2022-09-27
  • 通讯作者: 赵健. E-mail:zhaojianjn@sdu.edu.cn

Primary mediastinal seminoma: a case report and literature review

CHEN Rong, LI Haichao, ZHAO Jian   

  1. Department of Thoracic Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Online:2020-02-10 Published:2022-09-27

摘要: 目的 提高对原发性纵隔精原细胞瘤的认识。 方法 回顾1例原发性纵隔精原细胞瘤的临床资料,并复习相关文献。 结果 病例为29岁男性,查体发现前纵隔肿物,既往诊断为唯支持细胞综合征(SCOS),AFP、β-HCG等相关血清学检测阴性,经手术完整切除,术后病理诊断为原发性纵隔精原细胞瘤,给予4周期含铂化疗,随访2年无复发迹象。 结论 手术治疗及化疗等综合治疗在原发性纵隔精原细胞瘤的治疗方案中占据重要的地位,尤其是预计可以完整切除的早期肿瘤。

关键词: 原发性纵隔精原细胞瘤, 手术, 化疗, 生殖细胞瘤, 唯支持细胞综合征

Abstract: Objective To improve the recognition of primary mediastinal seminoma. Methods The clinical data of 1 patient with primary mediastinal seminoma were described, and the relevant references were reviewed. Results The patient was 29 years old, and diagnosed as Sertoli cell only syndrome(SCOS)before. Physical examination was negative in serological tests of AFP, β-HCG and etc. The patient was pathologically diagnosed as primary mediastinal seminoma after surgery. Conclusion Surgery and chemotherapy play important roles in the treatment of primary mediastinal seminoma, especially for the early tumors that are expected to be completely resected.

Key words: Primary mediastinal seminoma, Surgery, Chemotherapy, Germ cell tumor, Sertoli cell only syndrome

中图分类号: 

  • R574
[1] Nichols CR. Mediastinal germ cell tumors: clinical features and biologic correlates[J]. Chest, 1991, 99(2): 472-479.
[2] 刘仁伟, 冯丰坔, 刘年元, 等. 纵隔原发性精原细胞瘤的CT表现[J]. 中国医学影像技术, 2012, 28(6): 1131-1134. LIU Renwei, FENG Fengdi, LIU Nianyuan, et al. CT characteristics of primary mediastinal seminoma [J]. Chin J Med Imaging Technol, 2012, 28(6): 1131-1134.
[3] Napieralska A, Majewski W, Osewski W, et al. Primary mediastinal seminoma[J]. J Thorac Dis, 2018, 10(7): 4335-4341.
[4] Cefaro GA, Luzi S, Turriziani A, et al. Primary mediastinal seminoma[J]. Br J Urol, 1988, 62(5): 461-464.
[5] Hainsworth JD. Diagnosis, staging, and clinical characteristics of the patient with mediastinal germ cell carcinoma[J]. Chest Surg Clin N Am, 2002, 12(4): 665-672.
[6] 高玉平, 刘强, 陈以明. 46例纵隔原发性生殖细胞肿瘤的临床病理学分析[J]. 上海交通大学学报(医学版), 2015, 35(5): 702-706. GAO Yuping, LIU Qiang, CHEN Yiming. Clinicopathological analysis of 46 cases of primary mediastinal germ cell tumors[J]. Journal of Shanghai Jiao Tong University Medical Science, 2015, 35(5): 702-706.
[7] 朱姗姗, 杨栋, 周旭辉. 女性原发性前纵隔精原细胞瘤一例报告及文献复习[J]. 中华肿瘤防治杂志, 2011, 18(11): 885-886.
[8] Rosadodechristenson M, Templeton P, Moran C. Mediastinal germ cell tumors: radiologic and pathologic correlation[J]. Radiographics, 1992, 12(5): 1013-1130.
[9] Simson LR, Lampe I, Abell MR. Suprasellar germinomas[J]. Cancer, 1968, 22(3): 533-544.
[10] 方三高, 李晟磊, 陈岗. 2015年WHO肺、胸膜、胸腺及心脏肿瘤分类(胸腺)解读[J]. 重庆医学, 2015, 44(36): 5041-5053.
[11] Mancini M, Carmignani L, Gazzano G, et al. High prevalence of testicular cancer in azoospermic men without spermatogenesis[J]. Hum Reprod, 2007, 22(4): 1042-1046.
[12] 海亚楠. BMP4在人睾丸Sertoli细胞的表达、功能、机制及与无精子症和精原细胞瘤的相关性研究[D]. 上海:上海交通大学, 2015.
[13] Faure AK, Pivot-Pajot C, Kerjean A, et al. Misregulation of histone acetylation in sertoli cell-only syndrome and testicular cancer[J]. Mol Hum Reprod, 2003, 9(12): 757-763.
[14] Puanglumyai S, Lekawanvijit S. An unusual case of sudden unexpected death due to massive hemopericardium from primary mediastinal seminoma[J]. Forensic Sci Int, 2017, 270: e1-e4. doi: 10.1016/j.forsciint.2016.10.003.
[15] Zhang H, Du Y, Liu W, et al. [A case report of primary mediastinal seminoma diagnosised as pulmonary fibrosis] [J]. Zhongguo Fei Ai Za Zhi, 2013, 16(10): 564-566.
[16] Bosemani T, Huisman T, Poretti A. Anti-ma2-associated paraneoplastic encephalitis in a male adolescent with mediastinal seminoma[J]. Pediatr Neurol, 2014, 50(4): 433-434.
[17] Chen CY, Tseng HS, Chen WY, et al. Brain infarction as the initial presentation of primary posterior mediastinal seminoma[J]. Acta Clin Belg, 2011, 66(5): 381-383.
[18] Shin MS, Odrezin GT, Van Dyke JA, et al. Unusual initial calcification of primary and metastatic seminomas: detection by computed tomography[J]. Chest, 1991, 99(6): 1543-1545.
[19] 王官良,罗华荣,沈双双,等.纵隔原发性精原细胞瘤的CT表现与病理对照[J]. 医学影像学杂志, 2013, 23(12): 1941-1943. WANG Guanliang, LUO Huarong, SHEN Shuangshuang, et al. CT features and pathologic findings of primary mediastinal seminoma[J]. J Med Imaging, 2013, 23(12): 1941-1943.
[20] Weissferdt A, Rodriguez-Canales J, Liu H, et al. Primary mediastinal seminomas: a comprehensive immunohistochemical study with a focus on novel markers[J]. Hum Patho, 2015, 46(3): 376-383.
[21] 牛晨,郭丽萍,令潇,等.罕见纵隔原发性精原细胞瘤的CT表现及临床特点[J].现代肿瘤医学, 2016, 24(24): 3937-3940. NIU Chen, GUO Liping, LING Xiao, et al. CT manifestations and clinical features of rare primary mediastinal seminoma[J]. Modern Ocology, 2016, 24(24): 3937-3940.
[22] 薛晨晖,赵兰空.原发性纵隔精原细胞瘤的CT诊断(附12例报告)[J]. 新疆医学, 2013, 43(1): 82-83.
[23] Ueno T, Tanaka YO, Nagata M, et al. Spectrum of germ cell tumors: from head to toe[J]. Radiographics, 2004, 24(2): 387-404.
[24] Fernández-Friera L, Fuster V, Sanz J. Characterization of a mediastinal thymic seminoma using cardiac magnetic resonance[J]. Rev Esp Cardiol(Engl Ed), 2012, 65(1): 97. doi: 10.1016/j.recesp.2010.03.005.
[25] Drevelegas A, Palladas P, Scordalaki A. Mediastinal germ cell tumors: a radiologic-pathologic review[J]. Eur Radiol, 2001, 11(10): 1925-1932.
[26] 李才林, 代云蒙, 曾珍,等. 精原细胞瘤的影像学表现及其病理学基础[J]. 实用放射学杂志, 2018, 34(2): 241-244. LI Cailin, DAI Yunmeng, ZENG Zhen, et al. Imaging features and pathological basis of seminoma[J]. J Pract Radio, 2018, 34(2): 241-244.
[27] Bukowski RM, Wolf M, Kulander BG, et al. Alternating combination chemotherapy in patients with extragonadal germ cell tumors: a southwest oncology group study[J]. Cancer, 1993, 71(8): 2631-2638.
[28] Sakurai H, Asamura H, Suzuki K, et al. Management of primary malignant germ cell tumor of the mediastinum[J]. Jpn J Clin Oncol, 2004, 34(7): 386-392.
[29] Bokemeyer C, Hartmann JT, Fossa SD, et al. Extragonadal germ cell tumors: relation to testicular neoplasia and management options[J]. APMIS, 2003, 111(1): 49-63.
[30] 王鹏远,段学宁,刘玉村,等.胸骨后甲状腺肿的诊断与手术治疗[J]. 中华普通外科杂志, 2008, 23(3): 209-211. WANG Pengyuan, DUAN Xuening, LIU Yucun, et al. Diagnosis and surgical therapy of substernal goiter[J]. Chinese Journal of General Surgery, 2008, 23(3): 209-211.
[31] Sakaguchi Y, Isowa N. Successful resection of mediastinal seminoma evaluated the response to induction chemotherapy with fluorodeoxyglucose-positron emission tomography[J]. Ann Thorac Cardiovasc Surg, 2012, 18(1): 45-47.
[32] Fedyanin M, Tryakin A, Bulanov A, et al. Chemotherapy efficacy and prognosis of patients with mediastinal seminoma. Single institution experience[J]. J Clin Oncol, 2016, 34(15_suppl): e16053.
[33] 付晓红. 霍奇金淋巴瘤预后因素研究及原发纵隔恶性生殖细胞瘤临床分析[D].广州:中山大学, 2008.
[34] Fizazi K, Culine S, Droz JP, et al. Initial management of primary mediastinal seminoma: radiotherapy or cisplatin-based chemotherapy?[J]. Eur J Cancer, 1998, 34(3): 347-352.
[35] Jyothirmayi R, Ramadas K, Jacob R, et al. Primary malignant germ cell tumours of the mediastinum - results of multimodality treatment[J]. Acta Oncol, 1997, 36(3): 317-321.
[36] Hartmann JT, Fossa SD, Nichols CR, et al. Incidence of metachronous testicular cancer in patients with extragonadal germ cell tumors[J]. J Natl Cancer Inst, 2001, 93(22): 1733-1738.
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