山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (5): 110-115.doi: 10.6040/j.issn.1671-7554.0.2019.071
• • 上一篇
徐文婷,李静,贾明旺,彭芳,杨嘉琳
XU Wenting, LI Jing, JIA Mingwang, PENG Fang, YANG Jialin
摘要: 目的 探讨妊娠期急性脂肪肝的临床特点。 方法 对2014年1月至2018年8月在广州医科大学附属第三医院就诊的63例妊娠期急性脂肪肝(AFLP)患者的临床资料进行回顾性分析,根据凝血酶原国际比值(INR)分为2组:≥1.5为重型组(n=32),<1.5为轻型组(n=31),观察两组临床特征、实验室检查指标、并发症、孕产妇及胎儿结局等情况。 结果 妊娠期急性脂肪肝患者多存在消化道症状,更多见于初产妇,且多采用剖宫产终止妊娠;患者具有异常的检验指标,其中轻型组丙氨酸氨基转移酶(ALT)、血小板(PLT)、凝血酶原活动度(PTA)、纤维蛋白原(FBG)高于重型组(P<0.05),总胆红素(TBIL)、直接胆红素(DBIL)、白细胞(WBC)、肌酐(SCr)、INR低于重型组(P<0.05);重型组较轻型组更易并发子痫、低蛋白及急性肾损伤(AKI),P值分别为0.043、0.032、0.036。 结论 AFLP患者具有异常的ALT、PLT、PTA、FBG、INR、TBIL、DBIL、WBC、SCr指标;应根据凝血等指标积极补充相关物质,明确诊断后及时终止妊娠,进一步提高AFLP患者救治率。
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