代谢综合征与P波离散度关系的探讨

doi:10.6040/j.issn.1671-7554.0.2014.235

摘要/Abstract

摘要： 目的探讨代谢综合征及相关指标对P波离散度(Pd)的影响,揭示代谢综合征的促心律失常作用.方法选取代谢综合征患者86例,对照组102例,均行12导联同步体表心电图描记,分别测量最大P波时限(Pmax)、最小P波时限(Pmin)及Pd.结果与对照组相比,代谢综合征组Pd明显增高(47.31±12.18 vs 33.08±11.04, P=0.001),但Pmax和Pmin无明显差异(P>0.05).相关分析显示,Pd与体质量指数(BMI, P=0.001)、总胆固醇(TC, P=0.038)、甘油三酯(TG,P=0.001)、载脂蛋白B(Apo B, P=0.027)、收缩压(SBP,P=0.036)及舒张压(DBP,P=0.015)呈正相关性.多元回归分析显示,BMI(P=0.001)与Pd存在明显的关联性.结论 BMI是影响Pd大小的独立危险因素,控制代谢综合征及体质量指数为心律失常防治提供一种新的策略,尤其是心房颤动.

关键词: P波离散度, 心电图, 代谢综合征, 心房颤动

Abstract: Objective To investigate the effect of metabolic syndrome on P wave dispersion (Pd), in order to reveal its proarrhythmic effect. Methods A total of 86 patients with metabolic syndrome and 102 controls were enrolled in the study. The maximum P wave duration (P max) and minimum P wave duration (P min) were measured with 12-lead synchronous surface electrocardiogram (ECG), and Pd was calculated using P max minus P min. Results Compared with the controls, patients had significantly higher value of Pd (47.31±12.18 vs 33.08±11.04, P=0.001). However, there was no much difference in P max and P min between the two groups (P>0.05). Correlation analyses revealed positive correlation between Pd and body mass index (BMI, P=0.001), total cholesterol (TC, P=0.038), triglyceride (TG, P=0.001), apolipoprotein B (Apo B, P=0.027), systolic blood pressure (SBP, P=0.036) and diastolic blood pressure (DBP, P=0.015). Multiple linear regression analysis indicated distinct association between BMI and Pd (P=0.001). Conclusion BMI is an independent influencing factor of Pd. Controlling metabolic syndrome and BMI will provide a new approach for the prevention and treatment of arrhythmia, especially atrial fibrillation.

Key words: P wave dispersion, Metabolic syndrome, Atrial fibrillation, Electrocardiogram

中图分类号:

R543.3

张风雷, 郑曼, 张琦, 顾磊, 徐新生. 代谢综合征与P波离散度关系的探讨[J]. 山东大学学报（医学版）, 2015, 53(2): 52-55.

ZHANG Fenglei, ZHENG Man, ZHANG Qi, GU Lei, XU Xinsheng. Clinical study on the association between metabolic syndrome and P wave dispersion[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 52-55.

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