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山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (8): 118-121.

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喹硫平和阿立哌唑治疗双相情感障碍抑郁发作的疗效及安全性临床试验研究

李荟1,焦志安2,赵国庆2,吴汝慧3   

  1. 1. 山东大学医学院, 济南 250012; 2. 山东大学附属省立医院心理科, 济南 250021; 3. 惠民县医院, 山东 惠民 251700
  • 收稿日期:2009-02-19 发布日期:2009-08-16
  • 通讯作者: 焦志安(1964- ),男,教授,主要从事心境障碍研究。Email:jiaozhian@126.com
  • 作者简介:李荟(1982- ),女,硕士研究生,主要从事心境障碍研究。Email:lihui6086@126.com

Clinical trial of efficacy and safety of quetiapine and aripiprazole in the treatment of bipolar depression

LI Hui 1, JIAO Zhian 2, ZHAO Guoqing 2, WU Ruhui 3   

  1. 1. School of Medicine, Shandong University, Jinan 250012, China;
    2. Department of Psychology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;
    3. Huimin County Hospital, Huimin 251700, China
  • Received:2009-02-19 Published:2009-08-16

摘要:

目的探讨喹硫平和阿立哌唑治疗双相情感障碍抑郁发作的疗效及安全性。方法将80例符合CCMD3双相情感障碍抑郁发作诊断标准的患者分为喹硫平组和阿立哌唑组,每组40例。治疗周期为8周,评定工具包括蒙哥马利抑郁量表(MADRS)、副反应量表(TESS)及匹兹堡睡眠质量指数(PSQI)。结果治疗8周后,2组患者MADRS总分均显著减少(P<0.001)。喹硫平组和阿立哌唑组脱落率分别为12.5%和15.0%,2组不良反应发生率分别为22.5%和35.0%。2组患者治疗8周后PSQI总分均显著减少(P<0.01)。结论喹硫平和阿立哌唑对双相情感障碍抑郁发作的疗效均较好。

关键词: 双相情感障碍;抑郁发作;喹硫平;阿立哌唑

Abstract:

To determine the efficacy and safety of quetiapine and aripiprazole in the treatment of bipolar depression. MethodsA total of 80 patients with CCMD3 bipolar disorder experiencing a depressive episode were assigned to two groups treated with quetiapine (n=40) or aripiprazole (n=40) for 8 weeks. Measures included MontgomeryAsberg Depression Rating Scale (MADRS),Treatment Emergent Symptom Scale (TESS) and Pittsburgh Sleep Quality Index (PSQI). Results After 8 weeks′ of treatment, the total score of MADRS was significantly reduced in both groups (P<0.001). The expulsive rate of the quetiapine group and the aripiprazole group was 12.5% and 15.0%, respectively. The adverse effective rate of the two groups was 22.5% and 35.0%. The total score of PSQI was significantly reduced in both groups after the treatment of 8 weeks (P<0.01). ConclusionQuetiapine and aripiprazole are efficient in the treatment of bipolar depression.

Key words:  Bipolar disorder; Depressive episode; Quetiapine; Aripiprazole

中图分类号: 

  • R749.4
[1] 李馨1,张敬悬2,唐济生2. 重性抑郁障碍患者与正常人应对方式的对照研究[J]. 山东大学学报(医学版), 2012, 50(2): 135-140.
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