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山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (8): 122-124.

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围绝经期抑郁与女性激素水平的相关性

王梦欣,宋冬玲,崔明峰   

  1. 山东大学齐鲁医院心理科, 济南  250012
  • 收稿日期:2009-01-07 发布日期:2009-08-16
  • 通讯作者: 宋冬玲(1956- ),女,副主任护师,主要从事临床医疗管理工作研究。 Email:song.DL@163.com
  • 作者简介:王梦欣(1967- ),女,主管护师,主要从事心身疾病的心理评估研究。
  • 基金资助:

    山东省教育厅科技计划项目(J06L74)。

Female sex hormone levels and perimenopause depression disorder [WT]
WANG Mengxin, SONG Dongling, CUI Mingfeng

WANG Mengxin, SONG Dongling, CUI Mingfeng   

  1. Department of Psychology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2009-01-07 Published:2009-08-16

摘要:

目的探讨围绝经期抑郁患者女性激素水平与抑郁的关系。方法选择围绝经期抑郁患者100例设为抑郁组,围绝经期无抑郁健康者100例设为对照组;采用汉密顿抑郁量表(HAMD,24项)评定临床抑郁症状,采用化学发光法检测血清雌二醇(E2)、孕酮(P)水平。结果抑郁组E2检测结果与对照组比较差异无统计学意义(18.28±11.65 vs 21.31±10.97, P>0.05);P检测结果与对照组比较差异有统计学意义(0.97±0.25 vs 0.48±0.26, P<0.05);E2/P比值与对照组比较差异有统计学意义(21.30±11.97 vs 37.71±15.27, P<0.01); HAMD评定结果与P呈正相关,与E2/P比值呈负相关。结论围绝经期抑郁者内源性激素水平与健康者不同,雌激素和孕激素调节功能的紊乱可能是围绝经期抑郁发病机制之一。

关键词: 性激素;围绝经期;抑郁

Abstract:

To investigate the correlation between perimenopause depression disorder and female sex hormone levels. Methods100 perimenopausal women with depression disorder were assessed and 100 perimenopause ones without depression disorder served as controls. The Hamilton Depression Scale was used to evaluate their depressive symptoms. Chemiluminescence Determination was adopted to determine the serum E2 and P levels. Result① Level of E2 had no significant difference between the two groups (18.28±11.65 vs 21.31±10.97,  P>0.05). ②The depression group exhibited a significant increase in P level compared with the controls (0.97±0.25 vs 0.48±0.26, P<0.05). Moreover, the ratio of E2/P was statistically decreased in the depression group in contrast to the control group (21.30±11.97 vs 37.71±15.27, P<0.01). ③A positive correlation was found between P and HAMD, whereas a negative correlation between E2/P and HAMD was demonstrated. ConclusionDysfunction of E2 and P secretion might be involved in the mechanism of perimenopausal depression disorder.

Key words: Sex hormones; Perimenopause; Depression

中图分类号: 

  • R749.42
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