山东大学学报 (医学版) ›› 2024, Vol. 62 ›› Issue (6): 65-70.doi: 10.6040/j.issn.1671-7554.0.2024.0207
• 临床医学 • 上一篇
康随芳1,王迎雪2,张琪晨1,王志仑2,尹哲2,肖娟3,陈国玲1
KANG Suifang1, WANG Yingxue2, ZHANG Qichen1, WANG Zhilun2, YIN Zhe2, XIAO Juan3, CHEN Guoling1
摘要: 目的 观察系统性红斑狼疮(systemic lupus erythematosus, SLE)患者睑板腺形态和功能的异常及其对泪膜的影响。 方法 纳入SLE患者41例(82眼)作为SLE组、健康志愿者26例(52眼)作为对照组。采用Keratograph 5M眼表综合分析仪评估睑板腺缺失程度、LipiView干涉仪测量泪膜脂质层厚度(tear film lipid layer thickness, TFLLT)、双通道视觉质量分析系统(the double-pass Optical Quality Analysis System, OQAS II)测量泪膜动态客观散射指数(objective scatter index, OSI),采用裂隙灯显微镜观察睑缘、睑板腺分泌物、荧光素钠角膜染色(fluorescein cornea staining, FCS)及荧光素钠染色泪膜破裂时间(fluorescein breakup time, FBUT)。采用标准泪液检测滤纸条行泪液分泌试验Ⅰ(Schirmer Ⅰ test, SⅠt)。用Spearman秩相关分析评估睑板腺相关指标与泪膜功能相关指标间的相关性。 结果 与对照组相比,SLE组睑板腺缺失程度评分(meibomian gland dropout score, MGDS)、睑板腺分泌物评分(meibomian gland secretion score, MGSS)、睑缘评分(eyelid margin score, EMS)、泪膜动态OSI、FCS均较高,TFLLT、FBUT均较低,两组之间差异均有统计学意义(P均<0.05)。SLE组与对照组的SⅠt差异无统计学意义(P>0.05)。SLE组MGDS、MGSS、EMS均与FBUT呈负相关(rMGDS=-0.335,rMGSS=-0.424,rEMS=-0.318,P<0.05),MGDS与泪膜动态OSI呈正相关(r=0.254,P<0.05)。 结论 系统性红斑狼疮可引起睑板腺形态和功能的异常,从而导致泪膜脂质层变薄、泪膜稳定性下降。
中图分类号:
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