山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (9): 48-53.doi: 10.6040/j.issn.1671-7554.0.2019.527
• • 上一篇
吴成威,孙博实,周军德,蒋天明,迟强
WU Chengwei, SUN Boshi, ZHOU Junde, JIANG Tianming, CHI Qiang
摘要: 目的 通过对比择期结直肠癌患者术前口服多糖溶液及安慰剂的术后胰岛素抵抗及并发症情况,探讨其安全性、可行性及优势。 方法 将2017年4月至2018年12月哈尔滨医科大学附属第二医院普外科的病历资料进行回顾分析,80例结直肠癌患者包括多糖溶液组40例与对照组(安慰剂组)40例。比较两组患者的一般资料、稳态模型2胰岛素抵抗指数(HOMA2-IR)、稳态模型2胰岛素敏感指数(HOMA2-%S)、空腹血糖(FPG)、空腹胰岛素(FINS)、白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、术后并发症等情况,并进行统计学分析。 结果 (1)两组患者的一般资料差异无统计学意义,术中均未出现误吸。(2)两组患者术后FPG、FINS、HOMA2-IR均较术前升高,HOMA2-%S降低(P<0.05)。(3)多糖溶液组患者术后第1、3天的空腹血糖、空腹胰岛素、胰岛素抵抗指数小于对照组,胰岛素敏感指数高于对照组(P<0.05)。(4)多糖溶液组患者术后白细胞、C反应蛋白较对照组低(P<0.05)。(5)多糖溶液组患者术后首次排气时间早于对照组(P<0.05)。(6)两组患者在术后感染性并发症、住院时间、住院费用方面差异无统计学意义(P>0.05)。 结论 与对照组相比,术前口服多糖溶液不增加误吸风险,而且能显著降低术后胰岛素抵抗、增加胰岛素敏感性、促进肠道功能恢复,但是在住院时间、住院费用及并发症方面并无明显差异。
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