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山东大学学报（医学版） ›› 2015, Vol. 53 ›› Issue (11): 80-84.doi: 10.6040/j.issn.1671-7554.0.2015.317

• 临床医学 • 上一篇    下一篇

山东省皮肤恶性黑色素瘤患者的临床特征与预后危险因素分析(附61例报告)

张敏1, 穆晓楠2, 马伟元3, 党宁宁1, 张楠4   

  1. 1. 山东大学附属济南市中心医院皮肤科, 山东 济南 250013;
    2. 山东大学附属济南市中心医院保健科, 山东 济南 250013;
    3. 山东大学齐鲁医院皮肤科, 山东 济南 250012;
    4. 山东大学附属济南市中心医院肿瘤科, 山东 济南 250013
  • 收稿日期:2015-03-24 出版日期:2015-11-10 发布日期:2015-11-10
  • 通讯作者: 张楠.E-mail:znjnzxyy@126.com E-mail:znjnzxyy@126.com

Clinical features and prognostic factors of cutaneous malignant melanoma in Shandong Province: report of 61 cases

ZHANG Min1, MU Xiaonan2, MA Weiyuan3, DANG Ningning1, ZHANG Nan4   

  1. 1. Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    2. Department of Health Care, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    3. Department of Dermatology, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China;
    4. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2015-03-24 Online:2015-11-10 Published:2015-11-10

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摘要： 目的 分析山东省皮肤恶性黑色素瘤(CMM)患者的临床特征,并探讨其临床病理特征与预后的相关危险因素.方法 对2009年1月至2014年12月收治的CMM患者61例的临床特点与预后进行记录与随访,采用SPSS1 13.0软件,Kaplan-Meier法计算生存率, Log-rank 法比较各组的生存率,Cox 模型进行多因素分析.结果 61例患者1、3、5年生存率分别为82.0％、23.0％、16.4％.患者的5年生存率与临床分期、病变部位有无溃疡及是否接受手术切除有相关性(P均<0.01). Cox多因素分析显示,临床分期是CMM患者5年生存率的独立危险因素.结论 临床分期是山东省CMM患者不良预后的独立危险因素.

关键词: 生存分析, 皮肤恶性黑色素瘤, 山东省, 预后

Abstract: Objective To investigate the clinical features and prognostic factors of cutaneous malignant melanoma (CMM) in Shandong Province. Methods Clinical data of 61 CMM cases treated during Jan. 2009 and Dec. 2014 were retrospectively reviewed. The survival rates were calculated with Kaplan-Meier method and compared with log-rank test. The independent prognostic factors were evaluated with Cox regression multivariate analysis. Results The 1-year, 3-year and 5-year survival rates of the 61 patients were 82.0%, 23.0%, and 16.4%, respectively. The 5-year survival rate was significantly associated with clinical staging (P<0.01), ulceration (P<0.01), and operation (P<0.01). Clinical staging was the independent prognostic factor. Conclusion Clinical staging is the independent risk factor for poor survival rate in patients with CMM in Shandong Province.

Key words: Cutaneous malignant melanoma, Prognosis, Survival analysis, Shandong Province

中图分类号: 

  • R739.5
[1] Noveski L, Zhivadinovik J, Matveeva N. Prognostic factors of primary cutaneus melanoma[J]. Med Pregl, 2014, 67(11-12):392-398.
[2] Eriksson H, Frohm-Nilsson M, Järås J, et al. Prognostic factors in localized invasive primary cutaneous malignant melanoma:results of a large population-based study[J]. Br J Dermatol, 2015, 172(1):175-186.
[3] Gloster HM Jr, Brodland DG. The epidemiology of skin cancer[J]. Dermatol Surg, 1996, 22(3):217-226.
[4] Jeon SY, Hong JW, Lee S, et al. Long-term survival analysis and clinical follow-up in acral lentiginous malignant melanoma undergoing sentinel lymph node biopsy in korean patients[J]. Ann Dermatol, 2014, 26(2):177-183.
[5] Ozgen A. A single institution retrospective analysis of malignant melanoma[J]. J Cancer Res Ther, 2014, 10(1):38-42.
[6] Chi Z, Li S, Sheng X, et al. Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese:a study of 522 consecutive cases[J]. BMC Cancer, 2011, 11:85. doi:10.1186/1471-2407-11-85.
[7] Luk NM, Ho LC, Choi CL, et al. Clinicopathological features and prognostic factors of cutaneous melanoma among Hong Kong Chinese[J]. Clin Exp Dermatol, 2004, 29(6):600-604.
[8] Måsbäck A, Olsson H, Westerdahl J, et al. Prognostic factors in invasive cutaneous malignant melanoma:a population-based study and review[J]. Melanoma Res, 2001, 11(5):435-445.
[9] Bradford PT, Goldstein AM, McMaster ML, et al. Acral lentiginous melanoma:incidence and survival patterns in the United States, 1986-2005[J].Arch Dermatol, 2009, 145(4):427-434.
[10] Armstrong A, Powell C, Powell R, et al. Are we seeing the effects of public awareness campaigns? A 10-year analysis of breslow thickness at presentation of malignant melanoma in the south west of England[J]. J Plast Reconstr Aesthet Surg, 2014, 67(3):324-330.
[11] Roh MR, Kim J, Chung KY. Treatment and outcomes of melanoma in acral location in Korean patients[J]. Yonsei Med J, 2010, 51(4):562-568.
[12] Ishihara K, Saida T, Yamamoto A. Japanese skin cancer society prognosis and statistical investigation committee. updated statistical data for malignant melanoma in Japan[J]. Int J Clin Oncol, 2001, 6(3):109-116.
[13] 迟志宏, 盛锡楠, 李思明, 等. 357例中国皮肤黑色素瘤临床特征与预后分析[J]. 肿瘤防治研究, 2011, 38(11):1316-1319. CHI Zhihong, SHENG Xinan, LI Siming, et al. A clinical characters and prognosis analysis on 357 cases with cutaneous malign ant melanoma in China[J]. Cancer Research on Prevention and Treatment, 2011, 38(11):1316-1319.
[14] Cormier JN, Xing Y, Ding M, et al. Ethnic differences among patients with cutaneous melanoma[J]. Arch Intern Med, 2006, 166(17):1907-1914.
[15] Cascinelli N. Margin of resection in the management of primary melanoma[J]. Semin Surg Oncol, 1998, 14(4):272-275.
[16] Voss B, Wilop S, Jonas S, et al. Tumor volume as a prognostic factor in resectable malignant melanoma[J]. Dermatology, 2014, 228(1):66-70.
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