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山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (12): 94-98.doi: 10.6040/j.issn.1671-7554.0.2014.494

• 临床医学 • 上一篇    下一篇

能谱CT在肝细胞癌与肝内肿块型胆管细胞癌鉴别诊断中的应用价值

刘常绪1, 张成琪2, 王新怡2, 杨志强2   

  1. 1. 泰山医学院, 山东 泰安 271000;
    2. 山东大学附属千佛山医院影像科, 山东 济南 250014
  • 收稿日期:2014-07-28 修回日期:2014-11-24 发布日期:2014-12-10
  • 通讯作者: 张成琪。E-mail:chengqizhangsd@126.com E-mail:chengqizhangsd@126.com
  • 基金资助:
    山东省科技发展计划(2011GSF11828)

Application value of spectral CT imaging in differential diagnosis of hepatocellular carcinoma and hepatic mass-type cholangiocarcinoma

LIU Changxu1, ZHANG Chengqi2, WANG Xinyi2, YANG Zhiqiang2   

  1. 1. Taishan Medical University, Taian 271000, Shandong, China;
    2. Department of Medical Imaging, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2014-07-28 Revised:2014-11-24 Published:2014-12-10

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摘要： 目的 探讨能谱CT在肝细胞癌与肝内肿块型胆管细胞癌鉴别诊断中的应用价值。方法 行能谱CT扫描并经病理证实的肝癌患者34例(肝细胞癌20例、肝内肿块型胆管细胞癌14例),通过能谱分析软件,获取肿块内感兴趣区的碘基图、水基图及101组单能量图像,分析单能量55 Kev下对应的碘含量、水含量、能谱曲线及标准化后碘含量。用独立样本t检验分析上述参数。结果 肝细胞癌的碘含量、能谱曲线斜率、标准化后碘含量分别为(12.84±2.38)、(1.58±0.24)、(0.15±0.05)μg/cm3,肝内肿块型胆管细胞癌分别为(10.71±3.01)、(1.34±0.32)、(0.12±0.34)μg/cm3。肝细胞癌与肝内肿块型胆管细胞癌的碘含量、能谱曲线斜率、标准化后碘含量差异均有统计学意义(P<0.05)。肝细胞癌与肝内肿块型胆管细胞癌的水含量分别为(1041.05±6.47)、(1 038.74±8.54)mg/cm3,差异无统计学意义(P>0.05)。结论 能谱CT成像及多参数分析,对肝细胞癌与肝内肿块型胆管细胞癌鉴别诊断中有一定价值。

关键词: 能谱成像, 肝癌, 体层摄影术

Abstract: Objective To explore the application value of spectral CT imaging in the differential diagnosis of hepatocellular carcinoma and hepatic mass-type cholangiocarcinoma. Methods A total of 34 liver cancer cases, including 20 hepatocellular carcinoma and 14 hepatic mass-type cholangiocarcinoma, underwent spectral CT scan. Iodine concentration, water concentration and 101 sets of monochromatic images were generated with gemstone spectral imaging post-processing software. The iodine concentration, water concentration, spectrum energy curve and normalized iodine concentration were measured at the monochromatic energy 55 Kev. The results were analyzed with independent samples t test. Results In hepatocellular carcinoma, the iodine concentration, spectrum energy curve and normalized iodine concentration were (12.84±2.38), (1.58±0.24) and (0.15±0.05) μg/cm3; while in cholangiocarcinoma, those were (10.71±3.01), (1.34±0.32) and (0.12±0.34) μg/cm3. There were significant differences between those indexes (P<0.05). The water concentration in hepatocellular carcinoma and cholangiocarcinoma were (1 041.05±6.47) and (1038.74±8.54) mg/cm3, respectively, exhibiting no significant difference (P>0.05). Conclusion Spectral CT is helpful for the differential diagnosis of hepatocellular carcinoma and hepatic mass-type cholangiocarcinoma.

Key words: Liver cancer, Tomography, Spectral CT imaging

中图分类号: 

  • R735.7
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