关键词: 预后, 多元分析 , 化学栓塞, 治疗性, 肝肿瘤

Abstract: To analyse factors affecting the prognosis in patients with primary hepatic carcinoma treated with combinated transcatheter hepatic artery chemoembolization (TACE). Methods: A total of 141 consecutive patients including 125 men and 16 women (mean 52 years old, ranged from 21 to 76 years) with primary hepatic carcinoma were treated from January 1996 to June 1999. Of them, 17 received TACE and surgical resection, 17 received TACE and percutaneous ethanol injection (PEI), 100 only TACE, 7 transcatheter hepatic artery infusion (TAI). Cox′s regression analysis model was used to analyse the factors including sex, age, ALT, AFP, HbsAg, liver function (Child′s system), the way of treatment, tumor size and number , serum albumin, portal cancerous thrombus, tumor pattern and HbeAg（sle=0.2, sls=0.05）. Results: Total midsurvival time was 19 months(mean 23.59 months). Total survival rates of 1, 2, 3 and 5 years were 63.91%, 44.47%, 25.76% and 7.38% respectively(95% confidence limit). Multivariable analysis revealed significant prognostic factors as follows: age, liver function, the way of treatment, portal cancerous thrombus and tumor pattern（χ2=45.993, P=0.000?1）. Conclusion: In this study, age, liver function, portal cancerous thrombus and tumor pattern are the risk prognostic factors, and treatment way is a protective factor（χ2=45.993， P=0.000?1）.

Key words: Primary hepatic carcinoma, Chemoembolization, therapeautic, Prognosis, Multivariate analysis