放射性粒子植入的创新性临床研究

doi:10.6040/j.issn.1671-7554.0.2016.1240

摘要/Abstract

摘要： 放射治疗是治疗恶性肿瘤的重要手段之一。放射性粒子植入为近距离照射治疗,其特点为肿瘤局部控制率高且并发症发生率低,临床适应证不断拓展。近年来开展的结合3D打印模板的放射性粒子植入使该治疗更为规范,剂量学更为精准。在循证医学的基础上,创新个体化粒子植入治疗方案的实施,有可能取得更佳的成果。

关键词: 放射性粒子, 近距离放疗, 恶性肿瘤

Abstract: Radioactive seed brachytherapy is one of the most promising salvage therapies for many malignant tumors. Brachytherapy has advantages of high local control rate of tumors and low complication rate. Recently, the procedure of 3D print individual template and CT-guided ¹²⁵I seed implantation is normalized and the dosage is accurate. Based on evidence-based medicine, 3D print individual template and CT-guided implantation of ¹²⁵I seeds will produce satisfying clinical results.

Key words: Malignant tumor, Brachytherapy, Radioactive seed

中图分类号:

R730.55

申文江. 放射性粒子植入的创新性临床研究[J]. 山东大学学报（医学版）, 2017, 55(2): 1-3.

SHEN Wenjiang. Radioactive seeds implantation in tumor treatment[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 1-3.

参考文献

[1] Eifel PJ. Role of radiation therapy[J]. Best Pract Res Clin Obstet Gynaecol,2016 Nov 25. pii: S1521-6934(16)30140-7. doi: 10.1016/j.bpob gyn.
[2] Delaney G, Jacob S, Featherstone C, et al. The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines[J]. Cancer, 2005, 104(6): 1129-1137.
[3] 殷蔚伯, 谷铣之. 肿瘤放射治疗学[M]. 4版. 北京: 北京医科大学、中国协和医科大学联合出版社, 2008: 2-3.
[4] 郎锦义, 王培, 吴大可. 2015年中国大陆放疗基本情况调查研究[J]. 中华放射肿瘤学杂志, 2016, 25(6): 541-545. LANG Jinyi, WANG Pei, WU Dake, et al. An investigation of the basic situation of radiotherapy in mainland China in 2015[J]. Chinese Journal of Radiation Oncology, 2016, 25(6): 541-545.
[5] DeVita VT Jr, Rosenberg SA. Two hundred years of cancer research[J]. N Engl J Med, 2012, 366(23):2207-2214.
[6] Hajdu SI. A note from history: landmarks in history of cancer[J]. Cancer, 2011, 117(5): 1450-1466.
[7] Rivard MJ, Butler WM, Devlin PM, et al. American Brachytherapy Society recommends no change for prostate permanent implant dose prescriptions using iodine-125 or palladium-103[J]. Brachytherapy, 2007, 6(1): 34-37.
[8] Stewart AJ, Drinkwater KJ, Laing RW, et al. The Royal College of Radiologists audit of prostate brachytherapy in the year 2012[J]. Clin Oncol, 2015, 27(6): 330-336.
[9] Stewart A, Parashar B, Patel M, et al. American brachytherapy society consensus guidelines for thoracic brachytherapy for lung cancer[J]. Brachytherapy, 2016, 15(1): 1-11.
[10] Verhoeff JJ, Stalpers LJ, Coumou AW, et al. Experimental iodine-125 seed irradiation of intracerebral brain tumors in nude mice[J]. Radia Oncol, 2007, 2(1): 1-7.
[11] Davis BJ, Horwitz EM, Lee WR, et al. American Brachytherapy Society consensus guidelines for transrectal ultrasound-guided permanent prostate brachytherapy[J]. Brachytherapy, 2012, 11(1): 6-19.
[12] 柴树德, 郑广钧, 毛玉权, 等. CT引导下经皮穿刺种植放射性¹²⁵I粒子治疗晚期肺癌[J]. 中华放射肿瘤学杂志, 2004, 13(4): 291-293. CHAI Shude, ZHENG Guangjun, MAO Yuquan, et al. Short-term efficacy of interstitial implantation of ¹²⁵I seeds combined with chemotherapy for advanced lung cancer[J]. Chinese Journal of Minimally Invasive Surgery, 2004, 13(4): 291-293.
[13] Huo X, Wang H, Yang J, et al. Effectiveness and safety of CT-guided ¹²⁵I seed brachytherapy for postoperative locoregional recurrence in patients with none-small cell lung cancer[J]. Brachytherapy, 2016, 15(3): 370-380.
[14] 姜玉良, 马月, 王俊杰. ¹²⁵I粒子治疗头颈部肿瘤颈淋巴结放疗后复发的结果分析[J]. 中华放射肿瘤学杂志, 2011, 20(2): 91-94. JIANG Yuliang, MA Yue, WANG Junjie, et al. Implantation of ¹²⁵I seeds for recurrence cervical node of head and neck tumor after external beam radiotherapy[J]. Chinese Journal of Radiation Oncology, 2011, 20(2): 91-94.
[15] 王皓, 王俊杰, 袁慧书, 等. CT引导¹²⁵I粒子植入治疗局部复发直肠癌疗效和剂量学分析[J]. 中华放射肿瘤学杂志, 2006, 15(4): 319-322. WANG Hao, WANG Junjie, YUAN Huishu, et al. Efficacy and dosimetry of computed tomography image-guided ¹²⁵I radioactive seed implantation for locally recurrent rectal cancer[J]. Chinese Journal of Radiation Oncology, 2006, 15(4): 319-322.
[16] Wang JJ, Yuan HS, Li JN, et al. CT-guided radioactive seed implantation for recurrent rectal carcinoma after multiple therapy[J]. Med Oncol, 2010, 27(2): 421-429.
[17] Guo JH, Teng GJ, Zhu GY, et al. Self-expandable esophageal stent loaded with ¹²⁵I seeds: initial experience in patients with advanced esophageal cancer[J]. Radiology, 2008, 247(2): 574-581.
[18] Chen Y, Wang XL, Yan ZP, et al. The use of ¹²⁵I seed strands for intraluminal brachytherapy of malignant obstructive jaundice[J]. Cancer Biother Radiopharm, 2012, 27(5): 317-323.
[19] Ge X, Ma J, Dai H, et al. Erratum to: clinical research on the treatment effects of radioactive(125)I seeds interstitial brachytherapy on children with primary orbital rhabdomyosarcoma[J]. Med Oncol, 2015, 32(1): 415. doi: 10.1007/s12032-014-0415-8.
[20] 王俊杰. 3D打印技术与精准粒子植入治疗学[M]. 北京: 北京大学医学出版社, 2016: 65-78.
[21] Huang MW, Liu SM, Zhang JG. A digital model individual template and CT-guided 125I seed implants for malignant tumors of the head and neck[J]. J Radiat Res, 2012, 53(6): 973-977.

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