认知催眠疗法减轻胃癌化疗患者癌因性疲乏的疗效观察

doi:10.6040/j.issn.1671-7554.0.2015.518

摘要/Abstract

摘要： 目的探讨认知催眠疗法在减轻胃癌患者化疗所致癌因性疲乏中的应用效果。方法将60例符合标准的胃癌化疗患者随机分为观察组和对照组,每组30例。2组患者均施行FOLFOX4方案化疗。于化疗第1天开始观察组给予认知催眠疗法,对照组给予常规健康教育,1次/d,每个化疗周期2次。于每周期化疗前、化疗结束后第5天和全部化疗结束后2个月分别评价2组患者的FACIT-F得分及TNF-α、IL-1β、IL-6水平。结果化疗前2组患者疲乏程度相当,FACIT-F评分无统计学差异(P>0.05)。化疗后2组FACIT-F评分呈下降趋势,对照组下降更明显,差异有统计学意义(P<0.01);2组TNF-α、IL-1β、IL-6水平呈增加趋势,对照组增加更明显,差异有统计学意义(P<0.01)。化疗结束后2个月观察组FACIT-F评分及TNF-α、IL-1β、IL-6水平仍高于对照组,差异具有统计学意义(P<0.05)。结论认知催眠疗法能够降低TNF-α、IL-1β、IL-6水平,明显改善胃癌化疗患者癌性疲劳,有望成为化疗所致癌因性疲乏的一种新的辅助治疗手段。

关键词: 认知催眠疗法, 化疗, 胃癌, 癌因性疲乏

Abstract: Objective To explore the effect of cognitive-behavioral therapy plus hypnosis to reduce cancer-related fatigue(CRF)in gastric cancer patients undergoing chemotherapy. Methods A total of 60 gastric cancer patients undergoing chemotherapy were randomly assigned to 2 groups: observation group(n=30)and control group(n=30). All patients adopted FOLFOX4 chemotherapy scheme. On day 1 of the treatment, the observation group underwent cognitive-behavioral therapy plus hypnosis, while the control group was provided with routine health education. The intervention was performed once a day, twice in each chemotherapy cycle. The score of FACIT-F, levels of TNF-α, IL-1β and IL-6 were measured at baseline, 5 days and 2 months after chemotherapy. Results There were no differences between the 2 groups in fatigue and FACIT-F score before chemotherapy(P>0.05). After chemotherapy, the FACIT-F scores of both groups decreased, and the control group had larger margin of decrease(P<0.01); the levels of TNF-α, IL-1β and IL-6 in both groups increased, and the control group had a larger margin of increase(P<0.05). Two months after chemotherapy, the observation group had higher FACIT-F score and higher levels of TNF-α, IL-1β and IL-6 than the control group(P<0.01). Conclusion Cognitive-behavioral therapy plus hypnosis is able to reduce TNF-α, IL-1β and IL-6 levels, and control fatigue in patients undergoing chemotherapy for gastric cancer. Therefore, it may serve as a promising auxiliary treatment for chemotherapy.

Key words: Chemotherapy, Gastric cancer, Cancer-related fatigue, Cognitive-behavioral therapy plus hypnosis

中图分类号:

R473.5

董秀红. 认知催眠疗法减轻胃癌化疗患者癌因性疲乏的疗效观察[J]. 山东大学学报（医学版）, 2016, 54(7): 56-59.

DONG Xiuhong. Effect of cognitive-behavioral therapy plus hypnosis in controlling cancer-related fatigue in gastric cancer patients receiving chemotherapy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 56-59.

参考文献

[1] Neefjes EC, van der Vorst MJ, Blauwhoff-Buskermolen S, et al. Aiming for a better understanding and management of cancer-related fatigue[J]. Oncologist, 2013, 18(10):1135-1143.
[2] Elkins G, Johnson A, Fisher W. Cognitive hypnotherapy for pain management [J]. Am J Clin Hypn, 2012, 54(4):294-310.
[3] Yellen SB, Cella DF, Webster K, et al. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy(FACT)measurement system[J]. J Pain Symptom Manage,1997, 13(2):63-74.
[4] Cella D, Eton DT, Lai JS, et al. Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy(FACT)Anemia and Fatigue scales[J]. J Pain Symptom Manage, 2002, 24(6):547-561.
[5] 张淼, 王维利, 赵江. 消化系统肿瘤患者癌因性疲乏症状体验的质性研究[J]. 护理学报, 2011, 18(4A):13-16.
[6] Kassam Z, Mackay H, Buckley CA, et al. Evaluating the impact on quality of life of chemoradiation in gastric cancer [J]. Curr Oncol, 2010, 17(4):77-84.
[7] 王海明, 李柏. 癌因性疲乏的诊断及治疗新进展[J]. 中国肿瘤临床与康复, 2014, 21(10):1274-1276.
[8] Kurzrock R. The role of cytokines in cancer-related fatigue [J]. Cancer, 2001, 92(6S):1684-1688.
[9] Collado-Hidalgo A, Bower JE, Ganz PA et al. Cytokine gene polymorphisms and fatigue in breast cancer survivors:early findings [J].Brain Behav Immun, 2008, 22(8):1197-1200.
[10] Lynn SJ, Green JP. The sociocognitive and dissociation theories of hypnosis:Toward a rapprochement [J]. Int J Clin Exp Hypn, 2011, 59(3):277-293.
[11] Elkins G, Johnson A, Fisher W. Cognitive hypnotherapy for pain management [J]. Am J Clin Hypn, 2012, 54(4):294-310.
[12] Van Belle S, Paridaens R, Evers G,et al. Comparison of proposed diagnostic criteria with FACT-F and VAS for cancer-related fatigue: proposal for use as a screening tool [J]. Support Care Cancer, 2005, 13(4):246-254.
[13] Hugh Dunstan R, Sparkes DL, Macdonald MM, et al. Altered amino acid homeostasis and the development of fatigue by breast cancer radiotherapy patients:a pilot study [J]. Clinical Biochemistry, 2011, 44(2-3):208-215.
[14] Mills PJ, Parker B, Dimsdale JE, et al. The relationship between fatigue and quality of life and inflammation during anthracycline-based chemotherapy in breast cancer[J]. Biol Psychol, 2005, 69(1):85-96.
[15] Alexander S, Minton O, Andrews P, et al. A comparison of the characteristics of disease-free breast cancer survivors with or without cancer-related fatigue syndrome [J]. Eur J Cancer, 2009, 45(3):384-392.

相关文章 15

[1]	张洁,赵颖慧,董雅琪,李娟,李培龙,杜鲁涛. GPR133基因甲基化在早期胃癌淋巴结转移预测中的作用[J]. 山东大学学报 (医学版), 2025, 63(3): 76-84.
[2]	陈文亮,王欢欢,郝金锦,弓蕊,赵强,张飞,高磊,董静逊. lncRNA PVT1表达在胃癌预后评估及恶性进展中的作用:基于列线图模型与细胞功能实验的研究[J]. 山东大学学报 (医学版), 2025, 63(10): 61-71.
[3]	李永,崔书君,杨飞,张凡,殷晓霞. 基于增强MRI的亚区域影像组学模型可预测乳腺癌患者新辅助化疗后的病理完全反应[J]. 山东大学学报 (医学版), 2025, 63(1): 81-89.
[4]	郭振江,王宁,赵光远,杜立强,崔朝勃,刘防震. 基于机器学习建立术前预测近端胃癌食管切缘阳性模型[J]. 山东大学学报 (医学版), 2024, 62(7): 78-83.
[5]	张荣雨,赵文,李洪欣,杨闯,王健,韩春燕,李际盛. 奥西替尼联合化疗一线治疗EGFR-RAD51融合突变转移性肺腺癌1例[J]. 山东大学学报 (医学版), 2024, 62(5): 116-120.
[6]	郭鑫,孟君,郑世良,董秀红. 老年胃癌患者衰弱与人体成分的相关性[J]. 山东大学学报 (医学版), 2024, 62(4): 40-47.
[7]	孙菁果,朱文帅,鲁艺,马晓丽,郏雁飞. 幽门螺杆菌感染对胃癌细胞m6A水平的影响及其机制[J]. 山东大学学报 (医学版), 2023, 61(9): 10-18.
[8]	樊荣,李彬彬,马晓丽,汪运山,郏雁飞. 胃癌中DEC2、HIF-2α的表达及临床意义[J]. 山东大学学报 (医学版), 2023, 61(7): 12-18.
[9]	穆彦熹,李金洲,陈康,梁红英,姚亚龙,汪文杰,陈晓. 443例胃癌根治术后发生肺部并发症的危险因素[J]. 山东大学学报 (医学版), 2023, 61(4): 37-41.
[10]	郭崇勇,赵朋,刘海盟,王强, 贾宗师,张建. 胸前丘疹为首发表现的胃癌1例[J]. 山东大学学报 (医学版), 2023, 61(4): 119-120.
[11]	王赞,徐晓涵,张瑜,曲业敏,王明义,陈艾. 幽门螺杆菌感染对胃癌细胞糖酵解的影响[J]. 山东大学学报 (医学版), 2023, 61(2): 16-24.
[12]	韩明勇,于晓黎,曾放平,谢兵,芦兰,瞿家权,江璧锋,唐斯晗,谭洁,梁瑾,钟龙辉,王柳,赵宣植. CT引导经皮肺穿刺肿瘤内化疗技术流程[J]. 山东大学学报 (医学版), 2023, 61(11): 11-19.
[13]	阮祥燕,程姣姣,杜娟,谷牧青. 卵巢组织冷冻保存[J]. 山东大学学报 (医学版), 2022, 60(9): 24-30.
[14]	付佳,王路路,胡帅,陈哲平,刘东义,李青松,卢国栋,张贺,赵鑫,冯昌. 不同入路腰方肌阻滞对胃癌根治患者术后恢复的影响[J]. 山东大学学报 (医学版), 2022, 60(8): 50-57.
[15]	秦静,杨飞,陈谦,夏涵岱,刘延国,王秀问. 晚期驱动基因阴性、PD-L1表达阴性非鳞非小细胞肺癌一线治疗方案的网状Meta分析[J]. 山东大学学报 (医学版), 2022, 60(7): 74-82.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed