Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (8): 18-26.doi: 10.6040/j.issn.1671-7554.0.2024.0503
LIU Shaoting1,2, ZHANG Weiwei2, RAN Qian2, WANG Jian1
CLC Number:
| [1] Union E. Regulation(EC)No 1333/2008 of the European Parliament and of the Council of 16 December 2008 on food additives[S]. 2008. [2] Cox S, Sandall A, Smith L, et al. Food additive emulsifiers: a review of their role in foods, legislation and classifications, presence in food supply, dietary exposure, and safety assessment[J]. Nutr Rev, 2021, 79(6): 726-741. [3] 徐宝财,王瑞,张桂菊,等.国内外食品乳化剂研究现状与发展趋势[J].食品科学技术学报,2017,35(4): 1-7. XU Baocai, WANG Rui, ZHANG Guiju, et al. Research progress and prospect in food emulsifiers[J].Journal of Food Science and Technology, 2017, 35(4): 1-7. [4] Shah R, Kolanos R, DiNovi MJ, et al. Dietary exposures for the safety assessment of seven emulsifiers commonly added to foods in the United States and implications for safety[J]. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2017, 34(6): 905-917. [5] Roca-Saavedra P, Mendez-Vilabrille V, Miranda JM, et al. Food additives, contaminants and other minor components: effects on human gut microbiota-a review[J]. J Physiol Biochem, 2018, 74(1): 69-83. [6] 王竹天.GB 2760-2014《食品安全国家标准 食品添加剂使用标准》实施指南[M].北京:中国质检出版社,2015. [7] National Institute of Health Sciences J. Japans Specifications and Standards for Food Additives(JSFA)[EB/OL].(2022-07-12)[2024-05-17]. https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/kenkou_iryou/shokuhin/syokuten/kouteisho9e.html. [8] Administration USPH. Food Code[EB/OL].(2023-01-18)[2024-05-17]. https://www.fda.gov/media/164194/download?attachment. [9] European Parliament, Council of the European Union. Regulation(EC)No 1333/2008 of the European Parliament and of the Council of 16 December 2008 on food additives(Text with EEA relevance)[EB/OL].(2008-12-16). [2024-05-17]. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32008R1333&qid=1725959469672 [10] Benard C, Cultrone A, Michel C, et al. Degraded carrageenan causing colitis in rats induces TNF secretion and ICAM-1 upregulation in monocytes through NF-kappaB activation[J]. PLoS One, 2010, 5(1): e8666. doi:10.1371/journal.pone.0008666. [11] Borthakur A, Bhattacharyya S, Dudeja PK, et al. Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells[J]. Am J Physiol Gastrointest Liver Physiol, 2007, 292(3): 829-838. [12] Chassaing B, van de Wiele T, De Bodt J, et al. Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation[J]. Gut, 2017, 66(8): 1414-1427. doi:10.1136/gutjnl-2016-313099. [13] Viennois E, Bretin A, Dubé PE, et al. Dietary emulsifiers directly impact adherent-invasive E.coli gene expression to drive chronic intestinal inflammation[J]. Cell Rep, 2020, 33(1): 108229. doi:10.1016/j.celrep.2020.108229. [14] Chassaing B, Koren O, Goodrich JK, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome[J]. Nature, 2015, 519(7541): 92-96. [15] Bhattacharyya S, Shumard T, Xie H, et al. A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity[J]. Nutr Healthy Aging, 2017, 4(2): 181-192. [16] Srour B, Kordahi MC, Bonazzi E, et al. Ultra-processed foods and human health: from epidemiological evidence to mechanistic insights[J]. Lancet Gastroenterol Hepatol, 2022, 7(12): 1128-1140. [17] Wu LM, Sankaran SJ, Plank LD, et al. Meta-analysis of gut barrier dysfunction in patients with acute pancreatitis[J]. Br J Surg, 2014, 101(13): 1644-1656. [18] de Haan JJ, Lubbers T, Derikx JP, et al. Rapid development of intestinal cell damage following severe trauma: a prospective observational cohort study[J]. Crit Care, 2009, 13(3): R86. doi:10.1186/cc7910. [19] Fekete E, Buret AG. The role of mucin O-glycans in microbiota dysbiosis, intestinal homeostasis, and host-pathogen interactions[J]. Am J Physiol Gastrointest Liver Physiol, 2023, 324(6): 452-465. [20] Lock JY, Carlson TL, Wang CM, et al. Acute exposure to commonly ingested emulsifiers alters intestinal mucus structure and transport properties[J]. Sci Rep, 2018, 8(1): 10008. doi:10.1038/s41598-018-27957-2. [21] Zangara MT, Ponti AK, Miller ND, et al. Maltodextrin consumption impairs the intestinal mucus barrier and accelerates colitis through direct actions on the epithelium[J]. Front Immunol, 2022, 13: 841188. doi:10.3389/fimmu.2022.841188. [22] Anderson JM, Van Itallie CM. Physiology and function of the tight junction[J]. Cold Spring Harb Perspect Biol, 2009, 1(2): a002584. doi:10.1101/cshperspect.a002584. [23] Poritz LS, Garver KI, Green C, et al. Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis[J]. J Surg Res, 2007, 140(1): 12-19. [24] 谭悦, 郑长清. 紧密连接蛋白occludin、ZO-1在溃疡性结肠炎中的表达及其临床意义[J]. 现代药物与临床, 2018, 33(7): 1803-1808. [25] Choi HJ, Kim J, Park SH, et al. Pro-inflammatory NF-κB and early growth response gene 1 regulate epithelial barrier disruption by food additive carrageenan in human intestinal epithelial cells[J]. Toxicol Lett, 2012, 211(3): 289-295. [26] Ogulur I, Yazici D, Pat Y, et al. Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80[J]. Allergy, 2023, 78(9): 2441-2455. [27] Khuda SE, Nguyen AV, Sharma GM, et al. Effects of emulsifiers on an in vitro model of intestinal epithelial tight junctions and the transport of food allergens[J]. Mol Nutr Food Res, 2022, 66(4): e2100576. doi:10.1002/mnfr.202100576. [28] Barbosa SJA, Oliveira MMB, Ribeiro SB, et al. The beneficial effects of Lacticaseibacillus casei on the small intestine and colon of Swiss mice against the deleterious effects of 5-fluorouracil[J]. Front Immunol, 2022, 13: 954885. doi:10.3389/fimmu.2022.954885. [29] Lu RH, Hu JH, Liu XX, et al. Mogroside-rich extract from Siraitia grosvenorii fruits protects against heat stress-induced intestinal damage by ameliorating oxidative stress and inflammation in mice[J]. Food Funct, 2023, 14(2): 1238-1247. [30] Bhatia R, Sharma S, Bhadada SK, et al. Lactic acid bacterial supplementation ameliorated the lipopolysaccharide-induced gut inflammation and dysbiosis in mice[J]. Front Microbiol, 2022, 13: 930928. doi:10.3389/fmicb.2022.930928 [31] 刘绍庭, 李忠俊, 陈立, 等. 食品添加剂羧甲基纤维素钠通过破坏肠内环境加剧辐射对小鼠肠道的损伤[J]. 陆军军医大学学报, 2024, 46(6): 522-534. LIU Shaoting, LI Zhongjun, CHEN li, et al. The food additive of Sodium Carboxymethylcellulose aggravated the damage of intestinal to mice by radiation by disrupting intestinal homeostasis[J]. J Amry Med Univ(J Third Mil Med Univ), 2024, 46(6): 522-534. [32] 孙凤娇, 李艳, 王雨心, 等. 膳食结构与硒对大鼠糖代谢的作用[J]. 山东大学学报(医学版), 2020, 58(2): 36-43. SUN Fengjiao, LI Yan, WANG Yuxin, et al. Effects of dietary structure and selenium concentration on glucose metabolism in rats[J]. Journal of Shandong University(Health Sciences), 2020, 58(2): 36-43. [33] 谌红珊, 陈垚, 刘晟忻, 等. 水摄入及其他膳食因素对血脂异常人群的影响[J]. 山东大学学报(医学版), 2015, 53(1): 81-86. CHEN Hongshan, CHEN Yao, LIU Shengxin, et al. Impact of water intake and other dietary factors on dyslipidemia population[J]. Journal of Shandong University(Health Sciences), 2015, 53(1): 81-86. [34] Perino A, Schoonjans K. Metabolic Messengers: bile acids[J]. Nat Metab, 2022, 4(4): 416-423. [35] Lv WW, Song JY, Nowshin Raka R, et al. Effects of food emulsifiers on high fat-diet-induced obesity, intestinal inflammation, changes in bile acid profile, and liver dysfunction[J]. Food Res Int, 2023, 173(1): 113302. doi:10.1016/j.foodres.2023.113302. [36] Tang Q, Wang C, Jin G, et al. Early life dietary emulsifier exposure predisposes the offspring to obesity through gut microbiota-FXR axis[J]. Food Res Int, 2022, 162(A): 111921. doi:10.1016/j.foodres.2022.111921. [37] Bhattacharyya S, O-Sullivan I, Katyal S, et al. Exposure to the common food additive carrageenan leads to glucose intolerance, insulin resistance and inhibition of insulin signalling in HepG2 cells and C57BL/6J mice[J]. Diabetologia, 2012, 55(1): 194-203. [38] Zhou JW, Wang F, Chen JJ, et al. Long-term kappa-carrageenan consumption leads to moderate metabolic disorder by blocking insulin binding[J]. Pharmacol Res, 2021, 165: 105417. doi:10.1016/j.phrs.2020.105417. [39] Laster J, Bonnes SL, Rocha J. Increased use of emulsifiers in processed foods and the links to obesity[J]. Curr Gastroenterol Rep, 2019, 21(11): 61. doi:10.1007/s11894-019-0723-4. [40] Singh RK, Wheildon N, Ishikawa S. Food additive P-80 impacts mouse gut microbiota promoting intestinal inflammation, obesity and liver dysfunction[J]. SOJ Microbiol Infect Dis, 2016, 4(1): 10. doi:10.15226/sojmid/4/1/00148. [41] Rousta E, Oka A, Liu B, et al. The emulsifier carboxymethylcellulose induces more aggressive colitis in humanized mice with inflammatory bowel disease microbiota than polysorbate-80[J]. Nutrients, 2021, 13(10): 3565. doi:10.3390/nu13103565. [42] Bhattacharyya S, Feferman L, Unterman T, et al. Exposure to common food additive carrageenan alone leads to fasting hyperglycemia and in combination with high fat diet exacerbates glucose intolerance and hyperlipidemia without effect on weight[J]. J Diabetes Res, 2015: 513429. doi:10.1155/2015/513429. [43] Elmén L, Zlamal JE, Scott DA, et al. Dietary emulsifier sodium stearoyl lactylate alters gut microbiota in vitro and inhibits bacterial butyrate producers[J]. Front Microbiol, 2020, 11: 892. doi:10.3389/fmicb.2020.00892. [44] Bancil AS, Sandall AM, Rossi M, et al. Food additive emulsifiers and their impact on gut microbiome, permeability, and inflammation: mechanistic insights in inflammatory bowel disease[J]. J Crohns Colitis, 2021, 15(6): 1068-1079. doi:10.1093/ecco-jcc/jjaa254. [45] Harusato A, Chassaing B, Dauriat CJG, et al. Dietary emulsifiers exacerbate food allergy and colonic type 2 immune response through microbiota modulation[J]. Nutrients, 2022, 14(23): 4983. doi:10.3390/nu14234983. [46] Viennois E, Merlin D, Gewirtz AT, et al. Dietary emulsifier-induced low-grade inflammation promotes colon carcinogenesis[J]. Cancer Res, 2017, 77(1): 27-40. [47] Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography[J]. Nature, 2012, 486(7402): 222-227. [48] Thum C, McNabb WC, Young W, et al. Prenatal caprine milk oligosaccharide consumption affects the development of mice offspring[J]. Mol Nutr Food Res, 2016, 60(9): 2076-2085. [49] Hsu CN, Lin YJ, Hou CY, et al. Maternal administration of probiotic or prebiotic prevents male adult rat offspring against developmental programming of hypertension induced by high fructose consumption in pregnancy and lactation[J]. Nutrients, 2018, 10(9):1229. doi:10.3390/nu10091229. [50] Xie RX, Sun Y, Wu JY, et al. Maternal high fat diet alters gut microbiota of offspring and exacerbates DSS-induced colitis in adulthood[J].Front Immunol, 2018, 9:2608. doi:10.3389/fimmu.2018.02608. [51] Liang YR, Liu DH, Li Y, et al. Maternal polysorbate 80 intake promotes offspring metabolic syndrome through vertical microbial transmission in mice[J]. Sci Total Environ, 2024, 909: 168624. doi:10.1016/j.scitotenv.2023.168624. [52] Jin G, Tang Q, Ma JH, et al. Maternal emulsifier P80 intake induces gut dysbiosis in offspring and increases their susceptibility to colitis in adulthood[J]. mSystems, 2021, 6(2): 1337-1320. [53] Yin LP, Zhang KY, Sun WC, et al. Carboxymethylcellulose based self-healing hydrogel with coupled DOX as Camptothecin loading carrier for synergetic colon cancer treatment[J]. Int J Biol Macromol, 2023, 249: 126012. doi:10.1016/j.ijbiomac.2023.126012. [54] Liu ZX, Liu Y, Liu H, et al. Design of carboxymethylcellulose-conjugated polymeric prodrug micelles for enhanced in vivo performance of docetaxel[J]. Int J Biol Macromol, 2023, 253(8): 127690. doi:10.1016/j.ijbiomac.2023.127690. [55] Zhang MK, Zhu L, Wu GC, et al. The impacts and mechanisms of dietary proteins on glucose homeostasis and food intake: a pivotal role of gut hormones[J]. Crit Rev Food Sci Nutr, 2023: 1-15. doi:10.1080/10408398.2023.2256400. [56] Miclotte L, de Paepe K, Rymenans L, et al. Dietary emulsifiers alter composition and activity of the human gut microbiota in vitro, irrespective of chemical or natural emulsifier origin[J]. Front Microbiol, 2020, 11: 577474. doi:10.3389/fmicb.2020.577474. [57] Zhang JH, Yu HL, Zhong H, et al. Dietary emulsifier glycerol monodecanoate affects the gut microbiota contributing to regulating lipid metabolism, insulin sensitivity and inflammation[J]. Food Funct, 2022, 13(17): 8804-8817. [58] Kajiwara-Kubota M, Uchiyama K, Asaeda K, et al. Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production[J]. NPJ Sci Food, 2023, 7(1): 10. doi:10.1038/s41538-023-00184-4. [59] Sandall A, Smith L, Svensen E, et al. Emulsifiers in ultra-processed foods in the UK food supply[J]. Public Health Nutr,2023, 26(11): 2256-2270. [60] 强龙征, 毛海光, 王梦婷, 等. 肠道类器官在肠疾病机制研究中的运用[J]. 生物化学与生物物理进展, 2024, 51(2): 394-403. QIANG Longzheng, MAO Haiguang, WANG Mengting, et al. Application of Intestinal Organoids in The Study of Intestinal Disease Mechanism[J]. Progress in Biochemistry and Biophysics, 2024, 51(2): 394-403. |
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