Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (5): 62-68.doi: 10.6040/j.issn.1671-7554.0.2019.1439

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Effect of intracavitary physiotherapy on pregnancy outcomes of 89 patients with thin endometrium in frozen-thawed embryo transfer cycles

ZHANG Xiuqing1,2, ZHANG Jing2, JIANG Qi2, LI Chen2, LIU Chang2, LI Ruijing2, FENG Huijuan3, GENG Ling1   

  1. 1. Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Health Management Department, Reproductive Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    3. Patient Service Center, Reproductive Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the effect of intracavitary physiotherapy on the pregnancy outcomes of patients with thin endometrium(TE)in frozen-thawed embryo transfer cycles. Methods Clinical data of 186 patients who underwent assisted reproduction technology(ART)but cancelled the frozen-thawed embryo transfer cycles at least twice due to endometrial thickness <8 mm during Jan. 2017 and Jun. 2018 were retrospectively analyzed. Those who were going to receive intracavitary physiotherapy during their new frozen-thawed embryo transfer cycles were enrolled into the treatment group(n=89), and the others who would not receive intracavitary physiotherapy were enrolled into the control group(n=97). According to the age, the patients were divided into group A(24-34 years old)and group B(35-42 years old). All patients received a high-quality blastocyst transfer in their new frozen-thawed embryo transfer cycles. The endometrial thickness, endometrial blood flow, biochemical pregnancy rate, biochemical miscarriage rate, clinical pregnancy rate, clinical miscarriage rate and live birth rate were compared. Results There were no significant differences in endometrial thickness before transplantation ［(group A:(0.74±0.11)mm vs(0.76±0.10)mm, P=0.422; group B:(0.73±0.11)mm vs(0.73±0.10)mm, P=0.854)］ and endometrial blood flow(group A: P=0.697; group B: P=0.835)between treatment group and control group in the age subgroups. In group A, there were no significant differences between treatment group and control group in biochemical pregnancy rate(65.5% vs 50.0%, P=0.103), clinical pregnancy rate(51.7% vs 46.0%, P=0.553)and live birth rate(37.9% vs 40.0%, P=0.826). In group B, compared with the control group, the treatment group had higher biochemical pregnancy rate(64.5% vs 38.3%, P=0.023), higher clinical pregnancy rate(61.3% vs 25.5%, P=0.002)and higher live birth rate(45.2% vs 21.3%, P=0.025)but lower biochemical miscarriage rate(5.0% vs 33.3%, P=0.038). Conclusion Intracavitary physiotherapy improves the pregnancy outcomes in women aged 35 to 42 with thin endometrium.

Key words: Intracavitary physiotherapy, Thin endometrium, Frozen-thawed embryo transfer, Pregnancy outcome

CLC Number: 

  • R715.2
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