Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (9): 38-42.doi: 10.6040/j.issn.1671-7554.0.2019.286

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Effects of multimodal analgesia under the guidance of enhanced recovery after open surgery on postoperative recovery of patients with colon cancer

ZHOU Jiahui1, WANG Gang2, LIU Jiang2, ZHAO Jian3, WANG Haifeng3, JIANG Zhiwei1,2,3   

  1. 1. Jinling Hospital, Nanjing Medical University, Nanjing 210002, Jiangsu, China;
    2. Department of General Surgery, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu, China;
    3.Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China
  • Published:2022-09-27

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Abstract: Objective To investigate the effects of multimodal analgesia(MMA)on postoperative recovery in patients undergoing open colon cancer surgery under the guidance of enhanced recovery after surgery(ERAS). Methods The clinical data of 62 patients from Jinling Hospital, Medical School of Nanjing University who underwent open colon cancer surgery during Jul. and Nov. 2018 were retrospective analyzed. The patients were divided into two groups: multimodal analgesia group(MMA group, n=31)and the patient-controlled intravenous analgesia group(PCIA group, n=31). The visual analogue score(VAS), recovery and incidence of complications 30 days after surgery were observed and compared between the two groups. Results Compared with the PCIA group, the MMA group needed shorter time for the first flatus ［(28.1±15.2)h vs(50.2±26.2)h,t=4.059,P<0.001］, first defecation［(38.9±19.4)h vs(62.6±25.8 h,t=4.085,P<0.001］, first off-bed activity［(17.6±9.3)h vs(30.0±13.4)h,t=4.259,<0.001］, first semi-liquid meal［(21.3±9.5)h vs(60.6±27.0)h,t=7.652,P<0.001］, and shorter postoperative stay ［(6.8±4.7)d vs(8.8±1.9)d, 山 东 大 学 学 报 (医 学 版)57卷9期 -周嘉晖,等.加速康复外科指导下的多模式镇痛对开腹结肠癌患者术后恢复的影响 \=-t=2.150,P=0.036］. The MMA group had better analgesia effect than the PCIA group, but there was no significant difference in the incidence of complications between the two groups 30 days after surgery. Conclusion Under the guidance of ERAS, multimodal analgesia can help the patients recovery. It is safe and effective, without increasing the risk of postoperative complications.

Key words: Multimodal analgesia, Colon cancer, Enhanced recovery after surgery, Postoperative recovery

CLC Number: 

  • R619
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