Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (2): 23-28.doi: 10.6040/j.issn.1671-7554.0.2018.1420

Previous Articles    

Risk factors affecting fertility and strategies for advanced age fertility

SUN Mei, CUI Wenjuan   

  1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics;
    The Key Laboratory for Reproductive Endocrinology(Shandong University)Ministry of Education;
    Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan 250021, Shandong, China
  • Published:2022-09-27

Abstract: The factors that affecting fertility are very complex. Age growth is the most irresistible factor for fertility decline. Other factors, including heredity, environment, psychosocial status and lifestyle, also accelerate the damage of fertility. With the progress of science and technology, many indicators were employed for fertility assessment. It is suggested that men and women at childbearing age, especially elderly couples, should timely accept fertility assessment to eliminate pregnancy-related risks, and correctly choose assisted reproductive technology or egg donation, and understand the upper limit of ART age.

Key words: Age, Fertility, Influencing factors, Fertility assessment, Advanced age fertility, In vitro fertilization

CLC Number: 

  • R711.6
[1] Gill SK, Broussard C, Devine O, et al. Association between maternal age and birth defects of unknown etiology: United States, 1997-2007[J]. Birth Defects Res Part A Clin Mol Teratol, 2012, 94(12): 1010-1018.
[2] Sharma R, Agarwal A, Rohra VK, et al. Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring[J]. Reprod Biol Endocrinol, 2015, 13: 35. doi:10.1186/s12958-015-0028-x.
[3] de La Rochebrochard E, de Mouzon J, Thépot F, et al. Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France[J]. Fertil Steril, 2006, 85(5): 1420-1424.
[4] Steiner AZ, Jukic AM. Impact of female age and nulligravidity on fecundity in an older reproductive age cohort[J]. Fertil Steril, 2016, 105(6): 1584-1588.
[5] De Vos M, Devroey P, Fauser BC. Primary ovarian insufficiency[J]. Lancet, 2010, 376(9744): 911-921.
[6] Franasiak JM, Forman EJ, Hong KH, et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening[J]. Fertil Steril, 2014, 101(3): 656-663.
[7] Revel A. Defective endometrial receptivity[J]. Fertil Steril, 2012, 97(5): 1028-1032.
[8] Stone BA, Alex A, Werlin LB, et al. Age thresholds for changes in semen parameters in men[J]. Fertil Steril, 2013, 100(4): 952-958.
[9] Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study[J]. J Clin Endocrinol Metab, 2002, 87(2): 589-598.
[10] Broer L, Codd V, Nyholt DR, et al. Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect[J]. Eur J Hum Genet, 2013, 21(10): 1163-1168.
[11] Moskovtsev SI, Willis J, Mullen JB. Age-related decline in sperm deoxyribonucleic acid integrity in patients evaluated for male infertility[J]. Fertil Steril, 2006, 85(2): 496-499.
[12] Curley JP, Mashoodh R, Champagne FA. Epigenetics and the origins of paternal effects[J]. Horm Behav, 2011, 59(3): 306-314.
[13] Schimmel MS, Bromiker R, Hammerman C, et al. The effects of maternal age and parity on maternal and neonatal outcome[J]. Arch Gynecol Obstet, 2015, 291(4): 793-798.
[14] Wennberg AL, Opdahl S, Bergh C, et al. Effect of maternal age on maternal and neonatal outcomes after assisted reproductive technology[J]. Fertil Steril, 2016, 106(5): 1142-1149.
[15] Morris JK, Wald NJ, Mutton DE, et al. Comparison of models of maternal age-specific risk for Down syndrome live births[J]. Prenat Diagn, 2003, 23(3): 252-258.
[16] 章小维, 郭明彩, 杨慧霞. 高龄初产对妊娠结局的影响[J]. 中国实用妇科与产科杂志, 2005, 21(2): 111-112. ZHANG Xiaowei, GUO Mingcai, YANG Huixia. The effects of first pregnancy in elder age on the prognosis[J]. Chinese Journal of Practical Gynecology and Obstetrics, 2005, 21(2): 111-112.
[17] Nybo Andersen AM, Urhoj SK. Is advanced paternal age a health risk for the offspring?[J] Fertil Steril, 2017, 107(2): 312-318.
[18] Chapman C, Cree L, Shelling AN. The genetics of premature ovarian failure: current perspectives[J]. Int J Womens Health, 2015, 7: 799-810. doi:10.2147/IJWH.S64024.
[19] 姜辉, 田杨, 黄锦, 等. 重视染色体基因缺陷对男性生育的影响[J]. 北京大学学报(医学版), 2012, 44(4): 504-506.
[20] Ramlau-Hansen CH, Thulstrup AM, Nohr EA, et al. Subfecundity in overweight and obese couples[J]. Hum Reprod, 2007, 22(6): 1634-1637.
[21] Chavarro JE, Rich-Edwards JW, Rosner BA, et al. Dietary fatty acid intakes and the risk of ovulatory infertility[J]. Am J Clin Nutr, 2007, 85(1): 231-237.
[22] Qiao J, Feng HL. Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence[J]. Hum Reprod Update, 2011, 17(1): 17-33.
[23] 卓胜楠, 张印峰, 张帅, 等. 不孕症女性体质量指数对IVF/ICSI-ET治疗结局的影响[J]. 生殖与避孕, 2013, 33(8): 534-540. ZHUO Shengnan, ZHANG Yinfeng, ZHANG Shuai, et al. Influence of body mass index on IVF/ICSI-ET treatment outcome among infertility women[J]. Reproduction and Contraception, 2013, 33(8): 534-540.
[24] 杨青萍. 卵巢储备功能与生育力减退影响因素的研究进展[J]. 医学综述, 2016, 22(11): 2158-2161. YANG Qingping. Research progress in the influence factors of ovarian reserve and fertility diminishment[J]. Medical Recapitulate, 2016, 22(11): 2158-2161.
[25] 白双勇,王剑松. 肥胖对男性精液影响的研究进展[J]. 医学综述, 2015, 21(17): 3087-3089. BAI Shuangyong, WANG Jiansong. Research progress in the effects of obesity on male semen[J]. Medical Recapitulate, 2015, 21(17): 3087-3089.
[26] Spandorfer SD, Kump L, Goldschlag D, et al. Obesity and in vitro fertilization: negative influences on outcome[J]. J Reprod Med, 2004, 49(12): 973-977.
[27] Zhang D, Zhu YM, Gao HJ, et al. Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women[J]. Gynecol Endocrinol, 2010, 26(5): 325-332.
[28] Colaci DS, Afeiche M, Gaskins AJ, et al. Mens body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization[J]. Fertil Steril, 2012, 98(5): 1193-1199.
[29] Petríková J, Lazúrová I. Ovarian failure and polycystic ovary syndrome[J]. Autoimmun Rev, 2012, 11(6-7): A471-478.
[30] La Marca A, Brozzetti A, Sighinolfi G, et al. Primary ovarian insufficiency: autoimmune causes[J]. Curr Opin Obstet Gynecol, 2010, 22(4): 277-282.
[31] Toufexis D, Rivarola MA, Lara H, et al. Stress and the reproductive axis[J]. J Neuroendocrinol, 2014, 26(9): 573-586.
[32] Pal L, Bevilacqua K, Santoro NF. Chronic psychosocial stressors are detrimental to ovarian reserve: a study of infertile women[J]. J Psychosom Obstet Gynaecol, 2010, 31(3): 130-139.
[33] 倪少凯, 吴柱国, 黄建初, 等. 东莞市不孕不育影响因素的调查与分析[J]. 广东医学院学报, 2010, 28(4): 364-367. NI Shaokai, WU Zhuguo, HUANG Jianchu, et al. Influencing factors of infertility in Dongguan City[J]. Journal of Guangdong Medical College, 2010, 28(4): 364-367.
[34] Han Y, Xia YK, Zhu PF, et al. Reproductive hormones in relation to polycyclic aromatic hydrocarbon(PAH)metabolites among non-occupational exposure of males[J]. Sci Total Environ, 2010, 408(4): 768-773.
[35] Cohn BA, Cirillo PM, Sholtz RI, et al. Polychlorinated biphenyl(PCB)exposure in mothers and time to pregnancy in daughters[J]. Reprod Toxicol, 2011, 31(3): 290-296.
[36] Eskenazi B, Warner M, Marks AR, et al. Serum dioxin concentrations and time to pregnancy[J]. Epidemiology, 2010, 21(2): 224-231.
[37] Axmon A, Thulstrup AM, Rignell-Hydbom A, et al. Time to pregnancy as a function of male and female serum concentrations of 2,2'4,4'5,5'-hexachlorobiphenyl(CB-153)and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene(p,p'-DDE)[J]. Hum Reprod, 2006, 21(3): 657-665.
[38] Li DK, Zhou ZJ, Miao MH, et al. Urine bisphenol-A(BPA)level in relation to semen quality[J]. Fertil Steril, 2011, 95(2): 625-630.
[39] Wirth JJ, Rossano MG, Potter R, et al. A pilot study associating urinary concentrations of phthalate metabolites and semen quality[J]. Syst Biol Reprod Med, 2008, 54(3): 143-154.
[40] Herr C, zur Nieden A, Koch HM, et al. Urinary di(2-ethylhexyl)phthalate(DEHP): metabolites and male human markers of reproductive function[J]. Int J Hyg Environ Health, 2009, 212(6): 648-653.
[41] Lin CM, Chang WP, Doyle P, et al. Prolonged time to pregnancy in residents exposed to ionising radiation in cobalt-60-contaminated buildings[J]. Occup Environ Med, 2010, 67(3): 187-195.
[42] Kesari KK, Agarwal A, Henkel R. Radiations and male fertility[J]. Reprod Biol Endocrinol, 2018, 16(1): 118.
[43] Hjollund NH, Storgaard L, Ernst E, et al. Impact of diurnal scrotal temperature on semen quality[J]. Reprod Toxicol, 2002, 16(3): 215-221.
[44] 白婷, 肖红梅, 卢光琇. 不孕症患者病因调查分析[J]. 生命科学研究, 2008, 12(3): 267-271. BAI Ting, XIAO Hongmei, LU Guangxiu. Investigation on etiological factors of infertile couples[J]. Life Science Research, 2008, 12(3): 267-271.
[45] Li Y, Lin H, Li YF, et al. Association between socio-psycho-behavioral factors and male semen quality: systematic review and meta-analyses[J]. Fertil Steril, 2011, 95(1): 116-123.
[46] Anifandis G, Bounartzi T, Messini CI, et al. The impact of cigarette smoking and alcohol consumption on sperm parameters and sperm DNA fragmentation(SDF)measured by Halosperm(®)[J]. Arch Gynecol Obstet, 2014, 290(4): 777-782.
[47] Lalinde-Acevedo PC, Mayorga-Torres BJM, Agarwal A, et al. Physically active men show better semen parameters than their sedentary counterparts[J]. Int J Fertil Steril, 2017, 11(3): 156-165.
[48] 高商, 袁聚祥, 韩宝生. 女性不孕相关危险因素的病例对照研究[J]. 中国妇幼保健, 2015, 30(18): 3014-3016. GAO Shang, YUAN Juxiang, HAN Baosheng. A case-control study on related risk factors of female infertility[J]. Maternal & Child Health Care of China, 2015, 30(18): 3014-3016.
[49] 李亚宁. 人工流产后不孕妇女的免疫学检查结果分析[J]. 医学与临床, 2011, 8(8): 970-971.
[50] 李晓梅. 高龄妇女再生育能力的孕前评估及干预措施[J]. 中国当代医药, 2018, 25(17): 29-32. LI Xiaomei. Pre-pregnancy assessment and intervention measures for the reproductive ability of elderly women[J]. China Modern Medicine, 2018, 25(17): 29-32.
[51] 孙瑜, 朱依敏. 高龄不育夫妇,现代辅助生殖技术之惑[J]. 中国计划生育和妇产科, 2014, 6(8): 1-3.
[52] American College of Obstetricians and Gynecologists Committee on Gynecologic Practice and Practice Committee. Female age-related fertility decline. Committee Opinion No. 589[J]. Fertil Steril, 2014, 101(3): 633-634.
[53] Goldman MB, Thornton KL, Ryley D, et al. A randomized clinical trial to determine optimal infertility treatment in older couples: the Forty and Over Treatment Trial(FORT-T)[J]. Fertil Steril, 2014, 101(6): 1574-1581.
[54] Qiao J, Wang ZB, Feng HL, et al. The root of reduced fertility in aged women and possible therapentic options: current status and future perspects[J]. Mol Aspects Med, 2014, 38: 54-85. doi:10.1016/j.mam.2013.06.001.
[55] Ethics Committee of the American Society for Reproductive Medicine. Oocyte or embryo donation to women of advanced reproductive age: an Ethics Committee opinion[J]. Fertil Steril, 2016, 106(5): e3-e7.doi:10.1016/j.Fertnstert.2016.07.002.
[1] LI Bo-Bo, LI Dao-Tang, LIU Shu-Guang, WANG Xing-Wu. Expression of serum DKK-1 in esophageal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 58-61.
[2] LI Ping, HE Xuemei. Fertility assessment of women [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 8-11.
[3] RUAN Xiangyan, CHENG Jiaojiao, DU Juan, GU Muqing. Ovarian tissue cryopreservation and preservation [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 24-30.
[4] WU Ruifang, LI Changzhong. Status and progress of female fertility protection [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 1-7.
[5] SHI Yuhua, PAN Ye, XIE Yanqiu. Latest advances of embryo cryopreservation technology [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 12-18.
[6] YAN Lei, YUE Caixin, LIU Yichun. Fertility preservation in patients with endometriosis [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 31-34.
[7] LU Qun, ZHAO Lulu. Progress on assisted reproductive technology for women with atypical endometrial hyperplasia and endometrial carcinoma receiving fertilitysparing treatment [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 35-41.
[8] LIN Yun, XIE Yanqiu. Fertility protection and preservation in breast cancer patients [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 42-46.
[9] HAO Guimin, LUO Zhuoye, WANG Yizhuo. Ethical issues and considerations in fertility preservation [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 47-52.
[10] XU Kai, HAN Chao, DING Shouluan, DING Xuan, XING Deguang, WANG Chengwei. Factors of preoperative rebleeding in 181 patients with poor-grade aneurysmal subarachnoid hemorrhage [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 97-101.
[11] XU Xiaofen, ZHU Xiao, MA Wei, LI Na. Influencing factors of cancer pain management disorder in 123 cancer patients [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 119-124.
[12] Qifeng YANG,Ning ZHANG. Sentinel lymph node biopsy of breast cancer in the era of precision medicine [J]. Journal of Shandong University (Health Sciences), 2022, 60(8): 1-5.
[13] Xiaofang YI,Jihua HUANG. Patient education and proper management of adenomyosis [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 32-35.
[14] Chao PENG,Yingfang ZHOU. Progress on the medical treatment of adenomyosis [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 20-25.
[15] Jinhua LENG,Jinghua SHI. Clinical manifestations of adenomyosis [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 1-5.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!