Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (10): 41-48.doi: 10.6040/j.issn.1671-7554.0.2021.0333

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Retrospective analysis of causes and clinical characteristics of 554 cases with hypokalemia in endocrinology department: a single-center study

FU Yilin, GUO Tian, GONG Ying, YAO Zhenyu, GUAN Qingbo, XU Chao, ZHOU Xinli, ZHANG Haiqing, ZHENG Dongmei, LIU Luna, ZHAO Jiajun   

  1. Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2021-10-15

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Abstract: Objective To explore the causes, clinical features and influencing factors of moderate to severe hypokalemia. Methods The clinical data of 554 hospitalized patients with hypokalemia treated in the Endocrinology Department of Shandong Provincial Hospital during Jan. 2006 and Dec. 2018 were retrospectively analyzed. The patients were divided into mild, moderate and severe groups according to the serum potassium levels. The influencing factors of hypokalemia were determined with Logistic regression analysis. Results The causes of hypokalemia were diabetes(n=109, 19.68%), hyperthyroidism(n=95,17.15%)and primary aldosteronism(n=64, 11.55%). With the severity of hypokalemia, the ratio of male, free triiodothyronine(FT3)and carbon dioxide combining power(CO2CP)increased, while age, total cholesterol(TC)level and low density lipoprotein-cholesterol(LDL-C)decreased. In Logistic regression analysis, except for hypokalemia caused by unknown causes, male(OR=2.071, P=0.001)was an influencing factor for moderate to severe hypokalemia, and patients with hyperthyroidism(OR=2.953, P<0.001), primary aldosteronism(OR=2.660, P=0.004), renal tubular acidosis(OR=4.967, P<0.001)and Gitelmans syndrome(OR=7.326, P=0.015)had a higher risk for the patients with moderate to severe hypokalemia than those with abnormal glucose metabolism. Conclusion Diabetes, hyperthyroidism and primary aldosteronism are influencing factors for hypokalemia. Gender and etiology are independent influencing factors for moderate to severe hypokalemia.

Key words: Hypokalemia, Endocrine metabolic disease, Etiology, Clinical characteristics, Related factor

CLC Number: 

  • R591.1
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