Abstract:

Objective   To investigate the changes and clinical significance of the concentration of serum high sensitivity of cardiac troponin T (hs-cTnT) in chronic heart failure (CHF).  Methods  A total of 147 patients with chronic heart failure were enrolled in the chronic heart failure group (CHF group), which was divided into 4 subgroups, and 30 healthy Objective   s were controls. The cardiac function of the patients was evaluated according to the standard of American New York Heart Association (NYHA). The blood samples of all patients and controls were collected, the concentrations of serum hs-cTnT and NT-proBNP were detected, and echocardiography was performed. Results  ① The concentration of serum hs-cTnT of the CHF group were higher than that of the control group (P<0.05). The concentrations of serum hs-cTnT were obviously different among the subgroups (P<0.05), and the worse the cardiac function was, the higher the serum hs-cTnT was. The echocardiographic parameters and NT-proBNP concentration of the CHF group and control group were statistically different (P<0.05). The echocardiographic parameters and NT-proBNP concentration of the subgroups of the CHF group were statistically different (P<0.05). ② Serum hs-cTnT of the CHF group was positively correlated with NT-proBNP, LAd, and LVEDd (r=0.680, 0.345 and 0.326, P<0.05), and negatively correlated with LVEF (r=-0.551, P<0.05). Conclusion  The concentration of the serum hs-cTnT is elevated and positively correlated to the severity of heart failure and concentration of plasma NT-proBNP, which can reflect patients’ cardiac function.

Key words: Chronic heart failure, High sensitivity of cardiac troponin T, NT-proBNP