JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (2): 20-24.doi: 10.6040/j.issn.1671-7554.0.2013.699

• Articles • Previous Articles     Next Articles

Inhibitive effect of SU11274 on human colon cancer (LOVO cell line)transplanted in nude mice

MENG Xian-peng1, LIU Jie2, SU Ya3, BING Xue4, GAO Wei2   

  1. 1. the 3rd Department of Medical Oncology, People′s Hospital of Dongping County, Dongping 271500, Shandong, China;
    2. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China;
    3. M. D. Program, Shanghai Medical College of Fudan University, Shanghai 200032, China;
    4. Graduate Department of Weifang Medical College, Weifang 261053, Shandong, China
  • Received:2013-11-20 Online:2014-02-10 Published:2014-02-10

PDF (PC)

248

Abstract:

Objective   To investigate the inhibitive effect of tyrosine kinase inhibitor SU11274 on the growth of human colon cancer (LOVO cell line) using a nude mice transplanted model. Methods  LOVO cancer cells were xenografted into 18 nude mice, which were then randomly divided into 3 groups: control group, high dose SU11274 treatment group (0.09mg/kg) and low dose SU11274 treatment group (0.0225mg/kg). Tumor growth was observed, the mice were weighed, and the tumor inhibition rate was calculated. The expression of c-Met was detected with immunohistochemical method, and HE staining was conducted. Results  The mean tumor volume in the high dose SU11274 treatment group was significantly lower than that in the control group (P<0.05). The tumor inhibition rate of the high dose SU11274 treatment group was much higher than that of the control group (56.25% vs 25.00%, P<0.05). Furthermore, the positive rate of c-Met expression was (45.83±8.61) % in the high dose SU11274 treatment group, and (66.67±16.63) % in the control group, with significant difference between the two groups (P<0.05). Conclusion  SU11274 could inhibit the human colon cancer cell transplanted tumor in nude mice.

Key words: Transplantation model of carcinoma, c-Met, SU11274, Colon cancer, Nude mice, Tumor inhibition rate

CLC Number: 

  • R735.3+5
[1] LIU Huiling, WANG Xingwen, FENG Shaobin, FENG Hong, HAN Junqing. Association between high expression of scavenger receptor class B type I and the prognosis of colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 84-89.
[2] ZHANG Xuequn, GAO Wei, PAN Pan, GAO Junyi. The expressions of PI3K/AKT and its related factors in colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 52-57.
[3] WANG Yao, CHEN Yan-hong, CHEN Hong. Correlation between sensibility, and side effects of 5-FU and DPYD gene polymorphisms in periphrel blood of patients with colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S1): 18-21.
[4] SUN Xiu-mei1, GAO Feng2, LIU Zi-feng3. Inhibition of Salinomycin on the characteristics of colon cancer stem cell [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(9): 40-44.
[5] LIU Chao1,2, QIN Zhong-ping3, WEI Feng-cai1, FAN Zhao-na1,2, ZHAO Wen-jing1,2, WANG Yu-min1,2, ZHUO Shao-yang1,2, CHEN Jian1,2, LIU Jing-pen. Comparision between cell suspension inoculation and
tissue block transplantation in establishment of
human hemangioma animal models [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(5): 46-50.
[6] CHU Qian-qian1, XU Gang2, REN Gui-jie1, XU Xia1, HU Zhong-yi1, LIU Yong-qing1, YUAN Hui-qing1, TIAN Ke-li1. Effect of rosiglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, in sensitizing 5-fluorouracil chemotherapy for colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(1): 66-71.
[7] JIANG Ying-jun1,2， KONG Xin-juan3， ZHANG Ke-shuang3， HU San-yuan1. Expression of c-Met and its role in development and  progression of colorectal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(5): 90-93.
[8] WANG Jing-nan 1，　ZHANG Nan-2，　ZHAO Jian-qiang 2，　GAO Ai-qin 3，　LIN Wen-li 3，　SUN Yu-ping 2. Expressions of hepatocyte growth factor and its receptor c-met in breast carcinoma and their relationship to lymphangiogenesis  and lymphatic metastasis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(3): 90-93.
[9] LI Wan-quan1, ZHU Xiao-lin2, YU Cheng-gong2. Effects of sodium butyrate on cell proliferation and expression of ICAM-1 in the HT-29 colon cancer cell line [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(11): 70-.
[10] ZHANG Yan-sheng,LIU Shao-hua,WEI Feng-cai,SUN Shan-zhen. Expressions of HGF and its receptor in oral squamous cell carcinoma and neck lymph nodes [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(4): 420-423.
[11] YANG Gao-yuan,RONG Feng-nian,ZHOU Ting. Effect of valproic acid on angiogenesis of human ovarian cancer in nude mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(11): 1034-1036.
[12] ZHAO Shan,RONG Feng-nian,ZHOU Ting. Inhibitory effect of valproic acid on human ovarian cancer in nude mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(3): 306-309.
[13] YANG Kui-zhong,SUN Xue-fei,XIANG Ji-shun,DU Qing-cong,HUANG Feng-chang. Inhibitory effect of c-FLIP-ASODN on transplantation tumor of esophagus cancer cell line EC109 in nude mice: an experimental study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(12): 1234-1238.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd