JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (2): 20-24.doi: 10.6040/j.issn.1671-7554.0.2013.699

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Inhibitive effect of SU11274 on human colon cancer (LOVO cell line)transplanted in nude mice

MENG Xian-peng1, LIU Jie2, SU Ya3, BING Xue4, GAO Wei2   

  1. 1. the 3rd Department of Medical Oncology, People′s Hospital of Dongping County, Dongping 271500, Shandong, China;
    2. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China;
    3. M. D. Program, Shanghai Medical College of Fudan University, Shanghai 200032, China;
    4. Graduate Department of Weifang Medical College, Weifang 261053, Shandong, China
  • Received:2013-11-20 Online:2014-02-10 Published:2014-02-10

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Abstract:

Objective   To investigate the inhibitive effect of tyrosine kinase inhibitor SU11274 on the growth of human colon cancer (LOVO cell line) using a nude mice transplanted model. Methods  LOVO cancer cells were xenografted into 18 nude mice, which were then randomly divided into 3 groups: control group, high dose SU11274 treatment group (0.09mg/kg) and low dose SU11274 treatment group (0.0225mg/kg). Tumor growth was observed, the mice were weighed, and the tumor inhibition rate was calculated. The expression of c-Met was detected with immunohistochemical method, and HE staining was conducted. Results  The mean tumor volume in the high dose SU11274 treatment group was significantly lower than that in the control group (P<0.05). The tumor inhibition rate of the high dose SU11274 treatment group was much higher than that of the control group (56.25% vs 25.00%, P<0.05). Furthermore, the positive rate of c-Met expression was (45.83±8.61) % in the high dose SU11274 treatment group, and (66.67±16.63) % in the control group, with significant difference between the two groups (P<0.05). Conclusion  SU11274 could inhibit the human colon cancer cell transplanted tumor in nude mice.

Key words: Transplantation model of carcinoma, c-Met, SU11274, Colon cancer, Nude mice, Tumor inhibition rate

CLC Number: 

  • R735.3+5
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