JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (2): 16-19.doi: 10.6040/j.issn.1671-7554.0.2013.234

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In vitro antibacterial activity of resveratrol against Enterococcus

SU Jun-hua1, SHI Dong-yan1, WANG Lei2, LI Wei-hao1, DU Su-ping3, LI Yong-jun1   

  1. 1. Department of Clinical Laboratory, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China;
    2. Department of Clinical Laboratory, Gaoyang County Hospital of Hebei Province, Gaoyang 071500, Hebei, China;
    3. Department of Gynecology and Obstetrics, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2013-04-01 Online:2014-02-10 Published:2014-02-10

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Abstract:

Objective   To investigate the antibacterial activity and ultrastructure changes of resveratrol (RES) against Enterococcus in vitro. Methods  Minimum inhibitory concentration (MIC) of RES against Enterococcus was tested with microdilution method according to the Guidelines of Clinical and Laboratory Standards Institute. Ultrastructure changes of Enterococcus against RES were observed with both scanning and transmission electron microscope. Results  MIC50 and MIC90 of RES against Enterococcus faecalis were 0.256mg/mL and 0.512mg/mL, and MIC50 and MIC90 of RES against Enterococcus faecom were 0.256mg/mL and 0.512mg/mL. Shrinkage and rupture of cell wall of Enterococcus was found with scanning and transmission electron microscope when cultivated with RES. Unclear structure of cell wall and organelles, and a large quantity of vacuoles in Enterococcus were observed with transmission electron microscope. Conclusion  The antibacterial activity of RES is confirmed by destroying the structure of Enterococcus.

Key words: Enterococcus, Scanning electron microscope, Resveratrol, Minimal inhibitory concentration, Transmission electron microscope

CLC Number: 

  • R378.1
[1] MIAO Yu-lian, WU Chuan-long, LIU Jin-bo, ZHANG Xiao-li. Effects of resveratrol on brain inflammation and the level of Aβ1-42 in hippocampus from ovariectomized obese rats fed with a high-fat diet [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(8): 17-21.
[2] FENG Xiao-wen, GAO Qing, DONG Hai-man, PENG Lei, YUE Qing-wei, ZHANG Jing, BAO Li-hua, LI Gui-bao, SUN Jin-hao, GAO Ying-mao. Protective effect of resveratrol on Aβ25-35-induced PC12 cell injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(4): 56-60.
[3] PENG Jie1, HAN Xue-ying2, HU Xiao-yan3, DENG Jing-ti3, GUO Yuan1. The effect of resveratrol on expression of IL-1β, IL-6, MCP-1 andSOCS1/3 in human peripheral blood mononuclear cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(11): 64-.
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