Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (8): 9-17.doi: 10.6040/j.issn.1671-7554.0.2023.0993

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Research advances in Vitamin K2 and pregnancy-related diseases

WANG Rui, YU Kang, LIU Yanping   

  1. Department of Nutrition, Peking Union Medical College Hospital, Beijing 100730, China
  • Published:2024-09-20

Abstract: Vitamin K2(VK2)is a vitamin that has been neglected for a long time. Recently, more and more evidences show that, in addition to the hepatic carboxylation of hemostatic related proteins, VK2 can play an important role in antioxidant, cardiovascular, bone metabolism and so on, which are closely related to pregnancy. Due to its possible deficiency status and good safety, VK2 has been added to some calcium supplements and multivitamin products used by pregnant women recently. However, to our knowledge, there is no review on the relationship between VK2 and pregnancy in the medical literature. This article aims to introduce the source and metabolic characteristics of VK2 in pregnancy, elaborate the possible relationship with pregnancy-specific diseases, evaluate the safety of supplementing VK2 in pregnant women, in order to provide reasonable suggestions for the use of VK2 supplements in pregnancy.

Key words: Pregnancy, Vitamin K2, Bone metabolism, Gestational hypertension, Leg cramps

CLC Number: 

  • R714
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