Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (12): 31-38.doi: 10.6040/j.issn.1671-7554.0.2022.0693

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Effects of recombinant human luteinizing hormone addition on trigger day and afterwards on assisted pregnancy outcomes of long-acting protocol in luteal phase

HAN Xiaoting1,2, GAO Wenli1,3, WANG Ting1, ZHAO Junli1,4   

  1. 1.Reproductive Medicine Center, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China;
    2. Reproductive Medicine Center, Jiangmen Maternal and Child Healthcare, Jiangmen 529020, Guangdong, China;
    3. Reproductive Medicine Center, Xian Fourth Hospital, Xian 710005, Shaanxi, China;
    4. Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750004, Ningxia, China
  • Published:2022-12-01

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Abstract: Objective To investigate the effects of addition of recombinant human luteinizing hormone(r-hLH)on trigger day and afterwards on the outcomes of in vitro fertilization and intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET). Methods The clinical data of 912 cycles of serum luteinizing hormone(LH)level <1.2 IU/L on trigger day of long-acting protocol in luteal phase treated in the Reproductive Medicine Center of General Hospital of Ningxia Medical University during Jan. 2013 and Oct. 2018 were retrospectively analyzed. According to whether r-hLH was added on trigger day, oocyte retrieval day, and transplant day, the patients were divided into addition group(n=483)and non-addition group(n=429). According to whether they had live births, they were divided into non-live birth group(n=546)and live birth group(n=366). The clinical characteristics and pregnancy outcomes were compared and analyzed. The influencing factors of r-hLH addition and live birth rate were analyzed with binary Logistic regression. Results The clinical pregnancy rate, live birth rate, embryo implantation rate, multiple pregnancy rate, preterm birth rate, and abortion rate were higher in the addition group, but the difference was not statistically significant(all P>0.05). The incidence of ovarian hyperstimulation syndrome(OHSS)was lower in the addition group than in the non-addition group(3.26% vs 8.28%, P=0.001). Binary Logistic regression showed that high level of LH on gonadotropins(Gn)initiation day(OR: 1.597, 95%CI: 1.313-1.944, P<0.001), high level of LH on initiation day(OR: 2.361, 95%CI: 1.304-4.275, P=0.005)and high incidence of OHSS(OR: 2.514, 95%CI: 1.140-5.545, P=0.022)were risk factors of non-addition of r-hLH. Advanced age(OR: 1.042, 95%CI: 1.009-1.076, P=0.001)and high body mass index(BMI)(OR: 1.060, 95%CI: 1.015-1.106, P=0.011)were risk factors of low live birth rate, while transfer of two embryos was a protective factor(OR=0.554, 95%CI: 0.404-0.761, P<0.001). Conclusion Addition of r-hLH on trigger day and afterwards in patients with relatively excessive downregulation of long protocol can achieve satisfactory assisted pregnancy outcomes.

Key words: In vitro fertilization-embryo transfer, Recombinant human luteinizing hormone, Luteal support, Assisted pregnancy outcome

CLC Number: 

  • R711.74
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