Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (12): 59-64.doi: 10.6040/j.issn.1671-7554.0.2024.0760

• Mechanism and Treatment of Adolescent Psychiatric and Psychological Disorders • Previous Articles    

Association of 25(OH)D, IGF-I, anxiety and depression symptoms with non-suicidal self-injury in outpatient adolescents with psychiatric disorders

WANG Xinqi, XU Jingjing, XU Wangwang, ZHANG Yang, GAO Jin   

  1. Department of Clinical Psychology, Qilu Hospital(Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266035, Shandong, China
  • Published:2024-12-09

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Abstract: Objective To investigate the effects of 25-hydroxyvitamin D ［25(OH)D］, insulin-like growth factor I(IGF-I), and anxiety and depression symptoms on non-suicidal self-injury(NSSI)in outpatient adolescents with psychiatric disorders. Methods A total of 234 outpatient adolescents with psychiatric disorders were selected for observation. They were divided into two groups based on the presence of NSSI: a non-NSSI group(86 cases)and an NSSI group(148 cases). The patients were assessed using the Hamilton Depression Rating Scale(HAMD)and the Hamilton Anxiety Rating Scale(HAMA). Serum levels of 25(OH)D and IGF-I were measured. Differences in variables between the two groups were compared. Binary Logistic regression was used to determine the risk factors for NSSI, and receiver operating characteristic(ROC)curve analysis was conducted to estimate the optimal cut-off values. Results The HAMA and HAMD scores in the NSSI group were significantly higher than those in the non-NSSI group(P<0.001), and the 25(OH)D levels were significantly lower in the NSSI group(P=0.001). Regression analysis revealed that the severity of depression symptoms(OR=1.186, 95%CI=1.089-1.292, P<0.001)and 25(OH)D levels(OR=0.921, 95%CI=0.857-0.990, P=0.026)were the influencing factors for NSSI in outpatient adolescents with psychiatric disorders. ROC analysis indicated that 25(OH)D level ≤13.06 ng/mL and HAMD score ≥18.50 were the best cut-off values for the diagnosis of NSSI. Conclusion The levels of 25(OH)D and the severity of depression symptoms are the influencing factors for NSSI in outpatient adolescents with psychiatric disorders. Combined testing of these factors demonstrates good diagnostic predictive value.

Key words: Non-suicidal self-injury, 25-hydroxyvitamin D, Insulin-like growth factor-I, Anxiety symptoms, Depression symptoms

CLC Number: 

  • R395.1
[1] Glenn CR, Klonsky ED. Nonsuicidal self-injury disorder: an empirical investigation in adolescent psychiatric patients[J]. J Clin Child Adolesc Psychol, 2013, 42(4): 496-507.
[2] Gandhi A, Luyckx K, Baetens I, et al. Age of onset of non-suicidal self-injury in Dutch-speaking adolescents and emerging adults: an event history analysis of pooled data[J]. Compr Psychiatry, 2018, 80: 170-178. doi:10.1016/j.comppsych.2017.10.007.
[3] Xiao QQ, Song XZ, Huang LJ, et al. Association between life events, anxiety, depression and non-suicidal self-injury behavior in Chinese psychiatric adolescent inpatients: a cross-sectional study[J]. Front Psychiatry, 2023, 14: 1140597. doi:10.3389/fpsyt.2023.1140597.
[4] Hu ZZ, Yu HJ, Zou JZ, et al. Relationship among self-injury, experiential avoidance, cognitive fusion, anxiety, and depression in Chinese adolescent patients with nonsuicidal self-injury[J]. Brain Behav, 2021, 11(12): e2419. doi:10.1002/brb3.2419.
[5] Zheng Q, Liu J, Ji YJ, et al. Elevated levels of monocyte-lymphocyte ratio and platelet-lymphocyte ratio in adolescents with non-suicidal self-injury[J]. BMC Psychiatry, 2022, 22(1): 618. doi:10.1186/s12888-022-04260-z.
[6] Fikke LT, Melinder A, Landrø NI. The effects of acute tryptophan depletion on impulsivity and mood in adolescents engaging in non-suicidal self-injury[J]. Hum Psychopharmacol, 2013, 28(1): 61-71.
[7] Geng CM, Shaikh AS, Han WX, et al. Vitamin D and depression: mechanisms, determination and application[J]. Asia Pac J Clin Nutr, 2019, 28(4): 689-694.
[8] Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease[J]. Front Neuroendocrinol, 2013, 34(1): 47-64.
[9] Esnafoglu E, Ozturan DD. The relationship of severity of depression with homocysteine, folate, vitamin B12, and vitamin D levels in children and adolescents[J]. Child Adolesc Ment Health, 2020, 25(4): 249-255.
[10] Sharif MR, Madani M, Tabatabaei F, et al. The relationship between serum vitamin D level and attention deficit hyperactivity disorder[J]. Iran J Child Neurol, 2015, 9(4): 48-53.
[11] Bhalla S, Mehan S, Khan A, et al. Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions[J]. Neurosci Biobehav Rev, 2022, 142: 104896. doi:10.1016/j.neubiorev.2022.104896.
[12] Arinami H, Watanabe Y, Suzuki Y, et al. Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia[J]. Sci Rep, 2023, 13(1): 1148. doi:10.1038/s41598-023-28449-8.
[13] 汤毓华,张明园. 汉密顿抑郁量表(HAMD)[J]. 上海精神医学, 1984(2): 61-64.
[14] 汤毓华,张明园. 汉密顿焦虑量表(HAMA)[J]. 上海精神医学, 1984(2): 64-65.
[15] 袁睿, 杨燕贻, 王梓懿, 等. 青少年心理韧性与非自杀性自伤行为的关系: 有调节的中介模型[J]. 中国临床心理学杂志, 2024, 32(4): 843-849. YUAN Rui, YANG Yanyi, WANG Ziyi, et al. The relationship between resilience and non-suicidal self-injury behaviors in adolescents: a moderated mediation model[J]. Chinese Journal of Clinical Psychology, 2024, 32(4): 843-849.
[16] Syed S, Kingsbury M, Bennett K, et al. Adolescents knowledge of a peers non-suicidal self-injury and own non-suicidal self-injury and suicidality[J]. Acta Psychiatr Scand, 2020, 142(5): 366-373.
[17] Andrews T, Martin G, Hasking P, et al. Predictors of onset for non-suicidal self-injury within a school-based sample of adolescents[J]. Prev Sci, 2014, 15(6): 850-859.
[18] Valencia-Agudo F, Burcher GC, Ezpeleta L, et al. Nonsuicidal self-injury in community adolescents: a systematic review of prospective predictors, mediators and moderators[J]. J Adolesc, 2018, 65: 25-38. doi:10.1016/j.adolescence.2018.02.012.
[19] 任江苹, 贺燕, 安朝东, 等. 中学生抑郁情绪与非自杀性自伤的关系: 冲动性的中介作用[J]. 四川精神卫生, 2023, 36(5): 447-452. REN Jiangping, HE Yan, AN Chaodong, et al. Relationship between depressive mood and non-suicidal self-injury in middle school students: the mediating role of impulsivity[J]. Sichuan Mental Health, 2023, 36(5): 447-452.
[20] Nock MK, Prinstein MJ. A functional approach to the assessment of self-mutilative behavior[J]. J Consult Clin Psychol, 2004, 72(5): 885-890.
[21] Pollak OH, DAngelo EJ, Cha CB. Does function predict persistence? Nonsuicidal self-injury among adolescents during and after hospitalization[J]. Psychiatry Res, 2020, 286: 112839. doi:10.1016/j.psychres.2020.112839.
[22] Ferrara M, Terrinoni A, Williams R. Non-suicidal self-injury(Nssi)in adolescent inpatients: assessing personality features and attitude toward death[J]. Child Adolesc Psychiatry Ment Health, 2012, 6: 12. doi:10.1186/1753-2000-6-12.
[23] 张雅怡, 李晓娟, 李明玉,等. 叙事治疗对青少年抑郁症患者非自杀性自伤的干预效果:一项前瞻性随机对照研究[J]. 中国当代儿科杂志, 2024, 26(2): 124-130. ZHANG Yayi,LI Xiaojuan, LI Mingyu, et al. Intervention effect of narrative therapy on non-suicidal self-injury in adolescents with depressive disorder: a prospective randomized controlled study[J]. CJCP, 2024, 26(2): 124-130.
[24] Kaneko I, Sabir MS, Dussik CM, et al. 1, 25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D[J]. FASEB J, 2015, 29(9): 4023-4035.
[25] Patrick RP, Ames BN. Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior[J]. FASEB J, 2015, 29(6): 2207-2222.
[26] Lavigne JE, Gibbons JB. The association between vitamin D serum levels, supplementation, and suicide attempts and intentional self-harm[J]. PLoS One, 2023, 18(2): e0279166. doi:10.1371/journal.pone.0279166.
[27] Bot M, Milaneschi Y, Penninx BW, et al. Plasma insulin-like growth factor I levels are higher in depressive and anxiety disorders, but lower in antidepressant medication users[J]. Psychoneuroendocrinology, 2016, 68: 148-155. doi:10.1016/j.psyneuen.2016.02.028.
[28] Chigogora S, Zaninotto P, Kivimaki M, et al. Insulin-like growth factor 1 and risk of depression in older people: the English Longitudinal Study of Ageing[J]. Transl Psychiatry, 2016, 6(9): e898. doi:10.1038/tp.2016.167.
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