Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (8): 44-49.doi: 10.6040/j.issn.1671-7554.0.2021.1380

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Efficacy and prognostic factors of gamma knife in treating 81 cases of brain metastases from lung cancer

GAO Zhongxia1, ZHANG Ming1, FAN Mingde1, TAN Chenyang1, WANG Mengdi1, WANG Chao1, FAN Yuefei1, DING Shouluan2, WANG Chengwei1   

  1. 1. Department of Neurosurgery;
    2. Institute of Medical Sciences, The Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Published:2022-07-27

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Abstract: Objective To evaluate the efficacy of gamma knife in the treatment of brain metastases from lung cancer and to analyze factors affecting survival. Methods A total of 81 patients with brain metastases from lung cancer who received gamma knife treatment in the Neurosurgery Department of our hospital during May 2016 and June 2020 were selected for a retrospective study, and a database was established after follow-up. Overall survival was defined as the period from the time receiving gamma knife to the date of death or end of follow-up or the first loss of follow-up. The 6-month, 1-year and 2-year survival rate were calculated with Kaplan-Meier method, and the survival curve was plotted. The differences in survival rates were analyzed with Log-rank test. Factors affecting survival were analyzed with Cox multivariate regression. Results All patients were followed up, and 36 of the 81 patients died(44.44%)at the end of follow-up. The median overall survival was 23 months(95%CI: 14~26). The 6-month, 1-year and 2-year survival rate were 82.84%, 63.53% and 43.35%, respectively. The total volume of metastases(HR: 1.158, 95%CI: 1.079~1.242, P<0.001), age(HR: 2.666, 95%CI: 1.257~5.657, P=0.010 6), and marginal dose(HR: 0.392, 95%CI: 0.167~0.922, P=0.031 8) were factors affecting survival. Conclusions Patients with brain metastases from lung cancer who received gamma knife treatment in this study gained good efficacy, and their survival rate and survival time were improved. The total volume of metastases ≥16cm3, age ≥70 years, and marginal dose <17Gy were adverse prognostic factors(P<0.05).

Key words: Gamma knife, Stereotactic Radiosurgery, Brain metastases, Lung cancer, Survival, Prognostic factors

CLC Number: 

  • R651.1+9
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