Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (9): 1-8.doi: 10.6040/j.issn.1671-7554.0.2021.0949

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New practice of radio-immunotherapy for lung cancer

YU Jinming, YAN Weiwei, CHEN Dawei   

  1. Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong, China
  • Published:2021-10-15

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Abstract: In recent years, immunotherapy combined with radiotherapy(iRT)has attracted great attention in the field of oncology, and hundreds of large clinical trials on iRT are currently underway. Radiotherapy can cause immunogenic death of tumor cells, promote the release and presentation of tumor antigens, and activate T cells. Radiotherapy can also reshape the tumor microenvironment from immunosuppression to immune activation. Immune checkpoint inhibitors can not only relieve T cell inhibition but also normalize tumor vessels so as to improve tumor hypoxia and increase radiosensitivity, which is the basic principle of synergistic anti-tumor effect of radiotherapy and immunity. Now iRT is becoming more and more mature, but it also faces many challenges. This paper will review the development of immunotherapy and radiotherapy in recent years, and explore the timing, fractional dose and treatment-related toxicity of iRT.

Key words: Lung cancer, Radiotherapy, Immunotherapy, Immune checkpoint inhibitors

CLC Number: 

  • R734.2
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