Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (8): 32-37.doi: 10.6040/j.issn.1671-7554.0.2021.0877

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Applications and progress of immunotherapy in repeated implantation failure

DENG Xiaohui1,2, GUO Ling1,2   

  1. 1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2021-09-16

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Abstract: Repeated implantation failure(RIF)is a hot and difficult issue in the field of modern reproductive medicine, with numerous and complex pathogenic factors. With the rise of reproductive immunology, recent studies have found that immune factors play an important role in the process of embryo implantation, and targeted immunotherapy can improve the pregnancy outcome of some patients. This article reviews the pathogenesis of RIF immune factors and the progress in the application of related immunotherapy methods, hoping to provide references for future basic research and clinical treatment.

Key words: In vitro fertilization-embryo transfer, Repeated implantation failure, Immunotherapy

CLC Number: 

  • R392.69
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