Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (3): 55-59.doi: 10.6040/j.issn.1671-7554.0.2020.1614

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Effects of chronic endometritis on the pregnancy outcomes of patients with endometriosis-associated infertility

LIANG Yanchun1, YE Haihua2, LU Limei2, DAI Yujing3, CHENG Qianyi3, CHOI Unleng3, ZENG Hanqiu3, CHEN Xinghuan3, WANG Xing3, WEI Yajing1, YANG Ruyu1   

  1. 1. Department of Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China;
    2. Department of Gynecology, Wuming Maternal and Child Health Hospital of Nanning, Nanning 530100, Guangxi, China;
    3. Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong, China
  • Published:2021-04-06

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Abstract: Objective To investigate the risk factors of chronic endometritis(CE)in patients with endometriosis-associated infertility(EAI), and to explore the effects of CE on the pregnancy outcomes of such patients. Methods Patients undergoing laparoscopic and hysteroscopic surgery for infertility during June 1, 2018 and June 1, 2019 were collected. All cases were laparoscopically diagnosed and pathologically confirmed as endometriosis. According to the two different diagnostic criteria of CE, patients were divided into CE group and non-CE group. Risk factors of CE were analyzed. The cumulative pregnancy rates of the two groups at different time periods after surgery were compared. Results When ≥1 CD138 positively stained plasma cells observed in endometrial stroma under one high power field was used as the diagnostic criterion, the prevalence of CE in patients with EAI was 82.79%(101/122); fallopian tube adhesion(P=0.008)was the risk factor. When ≥5 CD138 positively stained plasma cells observed was used as the diagnostic criterion, the prevalence of CE was 54.1%(66/122); other gynecologic diseases(myoma, polycystic ovarian syndrome, etc.)(P=0.002)were the risk factor. Whatever the criterion was, after standardized antibiotic treatment, 6, 9 and 12 months after surgery, the differences in the cumulative pregnancy rates in patients with CE and without CE were not statistically significant(P>0.05). Conclusion The prevalence of CE in patients with EAI is high; fallopian tube adhesion and complicated gynecologic diseases are the risk factors of CE in such patients. Standardized antibiotic treatment can improve the pregnancy outcomes.

Key words: Chronic endometritis, Endometriosis, Infertility, CD138

CLC Number: 

  • R711.71
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