JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (3): 41-44.doi: 10.6040/j.issn.1671-7554.0.2015.407

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Preparation of self-microemulsifying drug delivery system for quercetin

ZHANG Weiling, LIU Xiaojuan   

  1. Department of Pharmacy, Liaoning Medical University, Jinzhou 121001, Liaoning, China
  • Received:2015-04-22 Online:2016-03-10 Published:2016-03-10

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Abstract: Objective To optimize the prescription of self-microemulsifying drug delivery system for quercetin(QT-SMEDDS)by central composite design-response surface method and prepare QT-SMEDDS. Methods Components of prescription was screened by measuring the solubility of quercetin in different secondary solvents, investigating the phase instability and plotting pseudo-ternary phase diagram. According to the balanced solubility and particle size of quercetin in different self-microemulsifying drug prescriptions, the optimal prescription was determined using central composite design-response surface methodology. The particle size and Zeta-potential were investigated in detail. Results The optimal prescription of quercetin in SMEEDS was composed of Labrafil M1944CS(oil), Cremophor EL(surfactant), and Transcutol HP(co-surfactant), with a weight ratio of 27.0%∶55.6%∶17.4%. The balanced solubility was 67.87 mg/g, the average particle size diluted 50 times with water was 25.26 nm, and Zeta-potential was -6.73 mV. Conclusion The optimized prescription of QT-SMEDDS is obtained and its quality is stable.

Key words: Self-microemulsifying drug delivery system, Quercetin, Central composite design-response surface method

CLC Number: 

  • R943
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