双酚A对大鼠椎体及股骨骨密度的影响

doi:10.6040/j.issn.1671-7554.0.2015.1119

Abstract

Abstract: Objective To observe the effects of different doses of bisphenol A(BPA)on the bone mineral densities(BMDs)of vertebrate and femoral bone in female F344 rats. Methods A total of 40 female F344 rats aged 4 weeks, bodyweight(53.90±4.23)g, were randomly divided into 5 groups: control group, BPA50 group［50 mg/(kg·d)］, BPA200 group［200 mg/(kg·d)］, BPA400 group［400 mg/(kg·d)］ and estradiol benzoate(EB)group［1 mg/(kg·3 d)］, with 8 rats in each group. BPA(diluted into corn oil)was given via gavage, EB was given via intraperitoneal injection, and the same volume of corn oil was given via gavage to the control group. The changes of mental state, body hair and bodyweight were recorded. The BMDs of vertebrate and femoral bone were measured after 13 weeks’ exposure by dual-energy X-ray absorptiometry(DEXA). Results The bodyweight of the BPA200 group was the lowest(P=0.003); the bodyweight of EB group was the highest(P=0.014); the bodyweight of the BPA400 group was significantly lower than that of the control group(P=0.015). BMD of vertebrate of the BPA200 group was the lowest and lower than that 山东大学学报 (医学版)54卷3期 -张婧,等.双酚A对大鼠椎体及股骨骨密度的影响 \=-of the control group(P=0.036); BMD of femoral bone of the BPA50 group was the lowest and significantly lower than that of the control group(P=0.027). BMD of vertebrate in the EB group was remarkably higher than that of the control group(P=0.018). Conclusion A certain doses of BPA can significantly reduce the bodyweight and the BMDs of vertebrate and femoral bone in female F344 rats.

Key words: Bone mineral density, Vertebrate, Bisphenol A, Estradiol benzoate, Femoral bone

CLC Number:

R589.5

ZHANG Jing, HAO Lanxiang, ZHANG Xiaochen, ZHANG Yonghong, FAN Shanshan, LIU Yan, JIANG Ling. Effects of bisphenol A on the bone mineral densities of vertebrate and femoral bone in rats[J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(3): 36-40.

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Effects of bisphenol A on the bone mineral densities of vertebrate and femoral bone in rats

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