JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (5): 85-88.doi: 10.6040/j.issn.1671-7554.0.2014.759

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Distribution pattern of cerebrovascular reactivity in healthy middle-aged or elderly people: a breath holding functional magnetic resonance imaging study

ZHANG Yang1, LI Wanhu2, SONG Weiyang1, LIU Chunlei1, ZHANG Quan1   

  1. 1. Department of Medical Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China;
    2. Department of Radiology, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong, China
  • Received:2014-10-28 Revised:2014-12-11 Online:2015-05-10 Published:2015-05-10

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Abstract: Objective To assess the distribution pattern of cerebrovascular reactivity (CVR) in healthy middle-aged or elderly people by using breath holding functional magnetic resonance imaging (fMRI). Methods Twenty-five middle-aged or elderly people were recruited and performed an fMRI with a breath holding task. Statistical parametric mapping 8 (SPM8) was applied in data processing to analyze the blood oxygen level dependent (BOLD) signal changes induced by breath holding. Differences in signal changes during breath holding were detected among the cortical territory supplied by the anterior cerebral artery, middle cerebral artery, posterior cerebral artery and basal ganglia regions. Results Increased BOLD signal induced by breath holding widely distributed in gray matter cortices and subcortical gray matter nuclei. The lowest percentage of BOLD signal change (PSC) was detected in the basal ganglia regions (P<0.001), and the posterior cerebral artery regions showed the highest PSC (P<0.05). Conclusion Breath holding fMRI is a convenient and reliable method for CVR assessing. Among healthy middle-aged or elderly people, the basal ganglia regions shows the lowest CVR while the PCA territory the highest.

Key words: Cerebrovascular reactivity, Breath holding, Magnetic resonance imaging, functional, Blood oxygen level dependent, Middle-aged or elderly people

CLC Number: 

  • R445.2
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