JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (1): 62-66.doi: 10.6040/j.issn.1671-7554.0.2015.258

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Two cases of multpile endoncrine neoplasia type 1 with Whipple syndrome

LI Dumin, WANG Qian, LI Chuanfu, WANG Qing   

  1. Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-03-11 Online:2016-01-11 Published:2016-01-11

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Abstract: Objective To analyze the CT and MRI features of two cases of multiple endocrine neoplasia type 1(MEN1), and improve the knowledge to it. Methods Lab examination, ultrsonography, CT and MRI enhancement scan were performed in two cases of MEN1 patients. Image findings were compared with the surgery of insulinoma resection and pathology. Results Eleven foci were found in operation. Four and six nodules were detected by CT and MRI, respectively. The nodules smaller than 0.5 cm were not found. Two, four and five lesions located at the head, body and tail of pancreas, respectively. One patient had pituitary microadenoma, the other had unilateral adrenal adenoma and bilateral parathyroid hyperplasia. Conclusion CT and MRI are valuable tools in the detection of multiple lesions of insulinoma in MEN1 patients but it is rather hard to determine the very small nodules.

Key words: Multiple endocrine neoplasia type 1, Insulinoma, MRI, CT

CLC Number: 

  • R445.2
[1] Kulke MH. Neuroendocrine tumours:clinical presentation and management of localized disease[J]. Cancer Treat Rev, 2003, 29(5):363-370.
[2] Carling T. Multiple endocrine neoplasia syndrome:genetic basis for clinical management[J]. Curr Opin Oncol, 2005, 17(1):7-12.
[3] Chung YJ, Hwang S, Jeong JJ, et al. Genetic and epigenetic analysis in Korean patients with multiple endocrine neoplasia type 1[J]. Endocrinol Metab(Seoul), 2014, 29(3):270-279.
[4] Piecha G, Chudek J, Wiecek A. Multiple Endocrine Neoplasia type 1[J]. Eur J Intern Med, 2008, 19(2):99-103.
[5] Falchetti A, Marini F, Luzi E, et al. Multiple endocrine neoplasia type 1(MEN1): not only inherited endocrine tumors[J]. Genet Med, 2009, 11(12):825-835.
[6] Horton KM, Hruban RH, Yeo C, et al. Multi-detector row CT of pancreatic islet cell tumors[J]. Radio Graphics, 2006, 26(2):453-464.
[7] Liu Y, Song Q, Jin HT, et al. The value of multidetector-row CT in the preoperative detection of pancreatic insulinomas[J]. Radiol Med, 2009, 114(8):1232-1238.
[8] Assignies G, Couvelard A, Bahrami S, et al. Pancreatic endocrine tumors: tumor blood flow assessed with perfusion CT reflects angiogenesis and correlates with prognostic factors[J]. Radiology, 2009, 250(2):407-416.
[9] Ichikawa T, Peterson MS, Federle MP, et al. Islet cell tumor of the pancreas: biphasic CT versus MR imaging in tumor detection[J]. Radiology, 2000, 216(1):163-171.
[10] Herwick S, Miller FH, Keppke AL. MRI of islet cell tumors of the pancreas[J]. AJR Am J Roentgenol, 2006, 187(5):W472-W480.
[11] 张静,林晓珠,陈克敏,等. MRI在胰岛素瘤诊断中的价值[J].放射学实践, 2012, 27(10):1105-1108. ZHANG Jing, LIN Xiaozhu, CHEN Kemin, et al. The value of MRI in the diagnosis of pancreatic insulinoma[J]. Radiol Practice, 2012, 27(10):1105-1108.
[12] 王鸥,邢小平,孟迅吾,等. MEN患者甲状旁腺功能亢进症的临床表现[J].中华内分泌代谢杂志, 2004, 20(4):296-299. WANG Ou, XING Xiaoping, MENG Xunwu, et al. Clinical manifestation of hyperparathyroidism in the patients with multiple endocrine neoplasia[J]. Chin J Endocrinol Metab, 2004, 20(4):296-299.
[13] Hellman P, Skogscid B, Oberg K, et al. Primary and reoperative parathyroid operations in hyperparathyroidism of multiple endocrine neoplasia typeⅠ[J]. Surgery, 1998, 124(6):993-999.
[14] Skogseid B, Rastad J, Gobl A, et al. Adrenal lesion in multiple endocrine neoplasia type 1[J]. Surgery, 1995, 118(6):1077-1082.
[15] Scarsbrook AF, Thakker RV, Wass JA, et al. Multiple endocrine neoplasia:spectrum of radiologic appearances and discussion of a multitechnique imaging approach[J]. Radiographics, 2006, 26(2):433-451.
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