阿米替林治疗痛性糖尿病周围神经病变的临床研究

doi:10.6040/j.issn.1671-7554.0.2014.948

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (5): 81-84.doi: 10.6040/j.issn.1671-7554.0.2014.948

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A clinic research of amitriptyline in treatment of painful diabetic peripheral neuropathy

SUN Zhuohao¹, LIU Yan², ZHOU Dongmei³, LI Wei³

1. Xuzhou Medical College, Xuzhou 221002, Jiangsu, China;
2. Department of Radiology, Zaozhuang Fourth Municipal Hospital, Zaozhuang 277500, Shandong, China;
3. Department of Endocrinology, the Affilicated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu, China

Received:2014-12-12 Revised:2015-03-25 Online:2015-05-10 Published:2015-05-10

Abstract

Abstract: Objective To observe the clinical effect of amitriptyline on the treatment of painful diabetic peripheral neuropathy (PDPN). Methods A total of 104 patients with diabetic peripheral neuropathy (DPN) were randomly divided into the case group (n=52) and control group (n=52). The case group was treated with amitriptyline, mecobalamine and epalrestat; while the control group was just treated with mecobalamine and epalrestat. The treatment lasted for 12 weeks. Nerve conduction velocity, visual analogue scale (VAS) of the two groups were compared before and after the treatment. Results Compared with the control group, the nerve conduction velocity of the case group was faster and VAS decreased (P<0.05). Conclusion The effect of using amitriptyline in treatment of PDPN is better.

Key words: Amitriptyline, Diabetic peripheral neuropathy, Neuropathy pain

CLC Number:

R589.1

SUN Zhuohao, LIU Yan, ZHOU Dongmei, LI Wei. A clinic research of amitriptyline in treatment of painful diabetic peripheral neuropathy[J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 81-84.

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