JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (3): 46-49.doi: 10.6040/j.issn.1671-7554.0.2014.951

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Effects of Flos Lonicerae Japonicae extract on pruritus induced by compound 48/80, histamine and substance P in ICR mice

BAI Xue1, HUANG Huifeng2, GUAN Yudong1, CHI Lianli1,3   

  1. 1. National Glycoengineering Research Center, Shandong University, Jinan 250100, Shandong, China;
    2. Zhejiang Sandoc Pharmaceutical Science and Technology Co., Ltd. Hangzhou 310000, Zhejiang, China;
    3. State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, Shandong, China
  • Received:2014-12-14 Revised:2015-01-14 Online:2015-03-10 Published:2015-03-10

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Abstract: Objective To study the effect of Flos Lonicerae Japonicae on pruritus induced by various pruritic agents including compound 48/80, histamine and substance P in mice. Methods Flos Lonicerae Japonicae extracts(0.3 g/kg, 0.8 g/kg and 2.4 g/kg) were respectively administered orally to ICR mice 1 h before the injection of compound 48/80, histamine and substance P. Immediately after the injection of pruritogens, the animals were put into the acrylic cage again, and their behaviors were videotaped. Results Flos Lonicerae Japonicae dose-dependently inhibited substance P-induced scratching. However, no inhibitory effect was observed on the scratching behavior induced by histamine or compound 48/80. Conclusion Flos Lonicerae Japonicae shows significant antipruritic effect on substance P-induced pruritus in ICR mice. The primary site of its antipruritic activity is epidermal keratinocytes rather than mast cells.

Key words: Itch-associated response, Extract, Substance P, Flos Lonicerae Japonicae

CLC Number: 

  • R285
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