JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (3): 46-49.doi: 10.6040/j.issn.1671-7554.0.2014.951

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Effects of Flos Lonicerae Japonicae extract on pruritus induced by compound 48/80, histamine and substance P in ICR mice

BAI Xue1, HUANG Huifeng2, GUAN Yudong1, CHI Lianli1,3   

  1. 1. National Glycoengineering Research Center, Shandong University, Jinan 250100, Shandong, China;
    2. Zhejiang Sandoc Pharmaceutical Science and Technology Co., Ltd. Hangzhou 310000, Zhejiang, China;
    3. State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, Shandong, China
  • Received:2014-12-14 Revised:2015-01-14 Online:2015-03-10 Published:2015-03-10

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Abstract: Objective To study the effect of Flos Lonicerae Japonicae on pruritus induced by various pruritic agents including compound 48/80, histamine and substance P in mice. Methods Flos Lonicerae Japonicae extracts(0.3 g/kg, 0.8 g/kg and 2.4 g/kg) were respectively administered orally to ICR mice 1 h before the injection of compound 48/80, histamine and substance P. Immediately after the injection of pruritogens, the animals were put into the acrylic cage again, and their behaviors were videotaped. Results Flos Lonicerae Japonicae dose-dependently inhibited substance P-induced scratching. However, no inhibitory effect was observed on the scratching behavior induced by histamine or compound 48/80. Conclusion Flos Lonicerae Japonicae shows significant antipruritic effect on substance P-induced pruritus in ICR mice. The primary site of its antipruritic activity is epidermal keratinocytes rather than mast cells.

Key words: Itch-associated response, Extract, Substance P, Flos Lonicerae Japonicae

CLC Number: 

  • R285
[1] Charlesworth EN, Beltrani VS. Pruritic dermatoses:overview of etiology and therapy[J]. Am J Med, 2002, 113(Suppl 9A):25S-33S.
[2] Lovell P, Vender RB. Management and treatment of pruritus[J]. Skin Therapy Lett, 2007, 12(1):1-6.
[3] Cunha PR, Delfini Filho O. Pruritus:still a challenge[J]. An. Bras. Dermatol, 2012, 87(5):735-741.
[4] Akiyama T, Carstens E. Neural processing of itch[J]. Neuroscience. 2013, 250:697-714. . doi:10.1016/j.neuroscience.2013.07.035. Epub 2013 Jul 24.
[5] Teresiak-Mikoajczak E, Czarnecka-Operacz M, Jenerowicz D, et al. Neurogenic markers of the inflammatory process in atopic dermatitis:relation to the severity and pruritus[J]. Postepy Dermatol Alergol, 2013, 30(5):286-292.
[6] Remröd C, Lonne-Rahm S, Nordlind K. Study of substance P and its receptor neurokinin-1 in psoriasis and their relation to chronic stress and pruritus[J]. Arch Dermatol Res, 2007, 299(2):85-91.
[7] Zhang Wei, Huang Luqi, Li Chaoxia, et al. Literature study on species of honeysuckle flower[J]. Chinese Journal of Chinese Materia Medica, 2014, 39(12):2239-2245.
[8] Wang Yadan, Yang Jianbo, Dai Zhong, et al. Research progress on Lonicerae Japonicae Flos[J]. Chin J Pharm Anal, 2014, 34(11):1928-1935.
[9] Zhang Q, Andoh T, Konno M, et al. Inhibitory Effect of Methanol Extract of Ganoderma lucidum on Acute Itch-Associated Responses in Mice[J]. Biol Pharm Bull, 2010, 33(5):909-911.
[10] Kim KH, Lee WR, An HJ, et al. Bee venom ameliorates compound 48/80-induced atopic dermatitis-related symptoms[J] . Int J Clin Exp Pathol, 2013, 6(12):2896-2903.
[11] Andoh T, Nagasawa T, Satoh M, et al. Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice[J]. J Pharmacol Exp Ther, 1998, 286(3):1140-1145.
[12] Tóth BI, Bíró T. TRP channels and pruritus[J]. The Open Pain Journa, 2013, 6(Suppl 1:M8):62-80.
[13] Inagaki N, Igeta K, Kim JF, et al. Involvement of unique mechanisms in the induction of scratching behavior in BALB/c mice by compound 48/80[J]. Eur J Pharmacol, 2002, 448(2-3):175-183.
[14] Ui H, Andoh T, Lee JB, et al. Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice[J]. Eur J Pharmacol, 2006, 530(1-2):172-178.
[15] Scholzen T, Armstrong CA, Bunnett NW, et al. Neuropeptides in the skin:interactions between the neuroendocrine and the skin immune systems[J]. Exp Dermatol, 1998, 7(2-3):81-96.
[16] Kulka M, Sheen CH, Tancowny BP, et al. Neuropeptides activate human mast cell degranulation and chemokine production[J]. Immunology, 2008, 123(3):398-410.
[17] Andoh T, Kuraishi Y. Nitric oxide enhances substance P-induced itch-associated responses in mice[J]. Br J Pharmacol, 2003, 138(1):202-208.
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