帕金森病肠功能分析及CXCR4在肠神经系统中的表达

doi:10.6040/j.issn.1671-7554.0.2013.692

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

Intestinal function analysis in Parkinson's disease and the expression of CXCR4 in the enteric nervous system

ZHANG Jing1, BAO Lihua1,2, WU Jintao1, LI Guibao1, LIU Haili1, YUE Qingwei1,ZHU Dexiao1, SUN Dong1, SONG Shouyang1, DING Zhaoxi1, SUN Jinhao1

1. Department of Human Anatomy, School of Medicine, Shandong University, Jinan 250012, Shandong， China;
2. Department of Neurology, the Peoples Hospital of Changzhi, Changzhi 046000, Shanxi， China

Received:2013-11-18 Online:2014-05-10 Published:2014-05-10

Abstract

Abstract: Objective To investigate the changes of intestinal function in rats with Parkinsons disease (PD) and explore the function and mechanism of CXCL12/CXCR4 in enteric nervous systems. Methods Twenty SD rats were randomly divided into 6-OHDA group and control group. In 6-OHDA group, SD rats were treated with 6-OHDA to establish PD model. Four weeks later, the one-hour fecal excretion and water content of the feces in two groups were measured.In addition, the expression of CXCR4 in the gastrointestinal nerve plexus was detected by immunofluorescent staining. Results Compared with those in the control group, the one-hour fecal excretion and water content of the feces in 6-OHDA group were significantly decreased(P<0.01). In 6-OHDA group, the number of CXCR4-positive cells in gastrointestinal nerve plexus was obviously decreased while the fluorescence intensity was increased (P<0.01). Conclusion Gastrointestinal dysfunction of PD rats may be related to the decreasing expression of CXCR4 in the enteric nervous systems.

Key words: 6-OHDA, Parkinson's disease, Entericnervous systems, CXCR4

CLC Number:

R742.5

ZHANG Jing1, BAO Lihua1,2, WU Jintao1, LI Guibao1, LIU Haili1, YUE Qingwei1,ZHU Dexiao1, SUN Dong1, SONG Shouyang1, DING Zhaoxi1, SUN Jinhao1. Intestinal function analysis in Parkinson's disease and the expression of CXCR4 in the enteric nervous system[J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(5): 25-29.

References

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