JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (11): 86-91.doi: 10.6040/j.issn.1671-7554.0.2014.298

Previous Articles     Next Articles

Ecological executive function in adolescent relatives of schizophrenia patients and its relationship with victimization

LI Yang1, CAO Fenglin1, ZHONG Gengkun2, LIN Pingzhen1, LIANG Xinhao1,2   

  1. 1. School of Nursing, Shandong University, Jinan 250012, Shandong, China;
    2. Shandong Mental Health Center, Jinan 250014, Shandong, China
  • Received:2014-05-08 Published:2014-11-10

PDF (PC)

547

Abstract: Objective To investigate specific executive deficits in the real-life environment among adolescent relatives of schizophrenia patients and to explore the effect of specific victimization types on the deficits. Methods The study included 104 non-affected adolescent descendants and siblings of schizophrenia patients in the relative group and 193 healthy adolescents in the healthy control group, all aged between 9 and 20 years. All participants completed the Behavior Rating Inventory of Executive Function-Self Report Version (BRIEF-SR) and Juvenile Victimization Questionnaire, Child Self-report Version (JVQ). Results The multivariate analysis revealed that the relative group reported more difficulties on the shift and task completion scale than controls (P<0.05). Significant main effects were detected for conventional crime on the plan/organize and task completion scale (P<0.05) and for child maltreatment on the inhibit, emotional control, monitor, working memory and organization of material scale (P<0.05). The univariate analysis revealed that in the relative group, adolescents who had experienced conventional crime reported higher scores on the plan/organize and task completion scale compared with those without conventional crime (P<0.05); adolescents with child maltreatment had higher scores on the Inhibit, emotional control, and organization of material scale than those without child maltreatment (P<0.05). For the healthy controls, adolescents with child maltreatment showed poorer scores on the Working Memory scale than those without maltreatment (P<0.05). Conclusion Our resultssuggest certain impaired aspects of executive functioning in real-life situations among adolescent relatives of schizophrenia patients. Conventional crime and child maltreatment may be associated with executive dysfunction in the adolescent relatives.

Key words: Schizophrenia, First-degree relatives, Executive function, Victimization, Adolescents

CLC Number: 

  • R749.3
[1] Heinrichs R W, Zakzanis K K. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence[J]. Neuropsychology, 1998, 12(3): 426-445.
[2] Mesholam-Gately R I, Giuliano A J, Goff K P, et al. Neurocognition in first-episode schizophrenia: a meta-analytic review [J]. Neuropsychology, 2009, 23(3): 315-336.
[3] Censits D M, Ragland J D, Gur R C, et al. Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study [J]. Schizophr Res, 1997, 24(3): 289-298.
[4] Jameson K G, Nasrallah H A, Northern T G, et al. Executive function impairment in first-degree relatives of persons with schizophrenia: A meta-analysis of controlled studies[J]. Asian J Psychiatry, 2011, 4(2):96-99.
[5] Keshavan M S, Diwadkar V A, Montrose D M, et al. Premorbid indicators and risk for schizophrenia: a selective review and update [J]. Schizophr Res, 2005, 79(1):45-57.
[6] Niemi L T, Suvisaari J M, Tuulio-Henriksson A, et al. Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies [J]. Schizophr Res, 2003, 60(2-3):239-258.
[7] Seidman L J, Giuliano A J, Smith C W, et al. Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside adolescent high risk studies [J]. Schizophr Bull, 2006, 32(3):507-524.
[8] Shaw P, Kabani N J, Lerch J P, et al. Neurodevelopmental trajectories of the human cerebral cortex [J]. J Neurosci, 2008, 28(14):3586-3594.
[9] Tsujimoto S. The prefrontal cortex: functional neural development during early childhood[J]. Neuroscientist, 2008, 14 (4):345-358.
[10] de la Serna E, Baeza I, Andres S, et al. Comparison between young siblings and offspring of subjects with schizophrenia: clinical and neuropsychological characteristics[J]. Schizophr Res, 2011, 131(1-3):35-42.
[11] Bhojraj T S, Diwadkar V A, Sweeney J A, et al. Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia [J]. Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(3):469-474.
[12] Ozan E, Deveci E, Oral M, et al. Neurocognitive functioning in a group of offspring genetically at high-risk for schizophrenia in Eastern Turkey[J]. Brain Res Bull, 2010, 82(3-4):218-223.
[13] McAuley T, Chen S, Goos L, et al. Is the behavior rating inventory of executive function more strongly associated with measures of impairment or executive function[J]. J Int Neuropsychol Soc, 2010, 16(3): 495-505.
[14] De Bellis M D, Hooper S R, Spratt E G, et al. Neuropsychological findings in childhood neglect and their relation-ships to pediatric PTSD [J]. J Int Neuropsychol Soc, 2009, 15(6): 868-878.
[15] DePrince A P, Weinzierl K M, Combs M D. Executive function performance and trauma exposure in a community sample of children [J]. Child Abuse Negl, 2009, 33(6): 353-361.
[16] Li Y, Dong F, Cao F, et al. Poly-victimization and executive functions in junior college students [J]. Scand J Psychol, 2013, 54: 485-492.
[17] 中华医学会精神科分会. 中国精神障碍分类与诊断标准第3版[M]. 济南: 山东科学技术出版社, 2001.
[18] Guy R M, Isquith P K, Gioia G A. Behavioral Rating Inventory of Executive Function-Self-Report Version Professional Manual [M]. Lutz, FL: Psychological Assessment Resources, Inc, 2004.
[19] Gioia G A, Isquith P K. Ecological assessment of executive function in traumatic brain injury [J]. Dev Neuropsychol, 2004, 25(1-2): 135-158.
[20] 杜巧新, 钱英, 王玉凤. 执行功能行为评定量表成人版自评问卷的信效度[J]. 中国心理卫生杂志, 2010, 24(9): 674-679. DU Qiaoxin, QIAN Ying, WANG Yufeng. Reliability and validity of the Behavior Rating Inventory of Executive Function, Adult Version Self-Report Form in China [J]. Chinese Mental Health Journal, 2010, 24(9): 674-679.
[21] 钱英, 王玉凤. 学龄儿童执行功能行为评定量表教师版信效度[J]. 中国心理卫生杂志, 2009, 23(10): 742-747. QIAN Ying, WANG Yufeng. Reliability and validity of the Behavior Rating Inventory of Executive Function, Teacher Form for School Age Children in China [J]. Chinese Mental Health Journal, 2009, 23(10): 742-747.
[22] Hamby S L, Finkelhor D, Ormrod R K, et al. The Juvenile Victimization Questionnaire (JVQ): administration and scoring manual [M]. Durham, NH: Crimes against Children Research Center, 2005.
[23] 程培霞, 曹枫林, 刘佳佳, 等. 青少年侵害问卷自评版用于中学生的信度和效度[J]. 中国心理卫生杂志, 2010, 18(4): 460-462. CHENG Peixia, CAO Fenglin, LIU Jiajia. Reliability and Validity of Chinese Self-report Version of Juvenile Victimization Questionnaire in Middle School Students [J]. Chinese Mental Health Journal, 2010, 18(4): 460-462.
[24] Diwadkar V A, Goradia D, Hosanagar A, et al. Working memory and attention deficits in adolescent offspring of schizophrenia or bipolar patients: comparing vulnerability markers[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2011, 35(5): 1349-1354.
[25] 钱英, 曹庆久, 王玉凤. 哌甲酯控释剂对注意缺陷多动障碍患儿生态学执行功能的影响[J]. 北京大学学报: 医学版, 2007, 39(3): 299-303. QIAN Ying, CAO Qingjiu, WANG Yufeng. Effect of extended-release methylphenidate on the ecological executive function for attention deficit hyperactivity disorder [J]. Journal of Peking University: Health Sciences, 2007, 39(3): 299-303.
[1] AN Di, WANG Xinting, LIU Zhenzhen, JIA Cunxian. Association between restless legs syndrome and suicidal behaviors among adolescents [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 77-82.
[2] LIU Yingjun, ZHANG Tao, WANG Lu, LIU Jia, CHANG Xuerun, ZHANG Jingxuan, XUE Fuzhong. Serum metabolic profiling of schizophrenia based on random forest [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 92-96.
[3] GONG qing, ZHANG Hao, QIAO Ying. Investigation on quality of life in family members of the schizophreniac [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(Z2): 177-178.
[4] GAO Wen, CAO Fenglin, CUI Naixue. Association between childhood trauma, early adulthood executive functions and negative emotions in medical students [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(9): 95-98.
[5] ZHAO Yan1, WANG Gang1, CHEN Dafang2, CHENG Yuhang1, CHEN Xueyan1. Plasma levels of IL-6, IL-10 and IL-12 and influencing factors in first-episode and neuroleptic-free schizophrenia patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(4): 70-73.
[6] YANG Li-min1,2, WANG Yan1, SUN Meng-meng2, CUI Kai-yan2, WANG Li-na2, LIU Lan-fen1,2. Information processing speed and related factors in first-episode schizophrenia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(9): 100-104.
[7] WANG Yan1, YANG Li-min1,2, SUN Meng-meng2, CUI Kai-yan2, YANG Xiao-dong2, QIAO Dong-dong1,2, WANG Ru-zhan2, ZHANG Jing-xuan2, LIU Lan-fen1,. Relationship between personality traits and childhood trauma in patients with schizophrenia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(8): 103-106.
[8] XU Yun-lu1, XU Cheng-min2. Relativities of stigma in schizophrenia with social support and consciousness of social face [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(11): 90-92.
[9] KANG Le1， WANG Jing1， WANG Xia2， ZHANG Na3， REN Jian-min1. Study of the plasma level of sRAGE and other related factors in
first-degree relatives  with normal glucose tolerance of Type 2 Diabetes [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(3): 1-4.
[10] LI Shu-li, ZHAO Jie, WANG Shi-lei. Relationship among self-regulated learning, study attribution and academic self-efficacy in left-behind adolescents   [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(9): 136-.
[11] LIU Zhenhua1, ZHENG Yunshao2, ZHANG Tianliang2, AN Luxuan1. Efficacy of paliperidone extended-release tablets on improving  social function in acute patients with schizophrenia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(8): 100-103.
[12] WANG Xia1, KANG Le1, WANG Jing1, ZHANG Na2, QIAO Zong-xing3, REN Jian-min1. Endothelial dysfunction and early atherosclerosis in first-degree relatives with normal glucose tolerance of type 2 diabetes mellitus patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(1): 1-5.
[13] LIU Xinfeng1, WEI Lingyun1, WANG Ping1, WANG Xia2. Antioxidant capacity in patients with type 2 diabetes and their first-degree relatives with normal glucose tolerance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(2): 10-13.
[14] . An investigation of mental health diathesis in adolescents [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(7): 117-121.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd