Abstract:

Objective   To observe the reflux characteristics of patients with reflux esophagitis in different body mass indexes using combined multichannel intraluminal impedance-pH (MII-pH) monitoring.  Methods   56 patients with reflux esophagitis were enrolled and divided into the normal group, overweight group and obesity group according to their body mass indexes. We observed reflux-related indicators of individuals with MII-pH monitoring, and then performed statistical analysis on pH monitoring and impedance results. Results   Compared with normal group, there were significant differences in overweight group and obesity group on percent time pH<4 (total, upright and recumbent), acid reflux and liquid reflux (P<0.05 or 0.01)，while no significant differences were found between overweight and obesity groups (all P>0.05). There were no significant differences in weakly acid reflux, non-acid reflux, mixed reflux, gas reflux and proximal reflux episodes among the three groups (all P＞0.05). Conclusion   There are more acid exposure, acid reflux and liquid reflux episodes in overweight and obese patients; however, the effect of the extent of obesity on acid exposure, acid reflux and liquid reflux has no significant difference.

Key words: Multichannel intraluminal impedance; pH monitoring; Body mass index; Reflux esophagitis; Overweight; Obesity