JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2013, Vol. 51 ›› Issue (1): 67-70.

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Expressions of Ki-67, PCNA and Survivin in gastrointestinal stromal tumor tissues

ZHANG Yan-xia1， ZHANG Pei-jun2， YAN Yan-yan3， DUAN Ai-xu4， LI Jia-shan2, NIU  San-qiang5   

  1. 1. Department of Pathology, Medical School， Shanxi Datong University；  2. Department of anatomy, Medical School，
    Shanxi Datong University；  3. Department of Pharmacology, Medical School， Shanxi Datong University；
    4. Department of Nursing, Medical School， Shanxi Datong University；
    5. Department of Pathology, Datong Third People’s Hospital， Datong 037009, Shanxi, China
  • Received:2012-07-13 Online:2013-01-10 Published:2013-01-10

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Abstract:

Objective   To investigate expressions of Ki-67, PCNA and Survivin in the gastrointestinal stromal tumor(GIST) tissues and the relationship with clinic pathological factors. Methods   The SP immunohistochemical assay was used to detect the expressions of Ki-67, PCNA and Survivin in 103 cases with GIST. Results   The Ki-67, PCNA and Survivin positive expression rates were 56.3%, 68.0% and 72.8%. There was no correlation between Ki-67, PCNA, Survivin expressions and the age, sex,  location and histological type. The expressions of Ki-67, PCNA and Survivin were related to the NIH grade. There were significant positive correlations among Ki-67, PCNA and Survivin expressions. Conclusion   Ki-67,  PCNA and Survivin can be used as the predictor for the malignant degree and prognosis of GIST.

Key words: Gastrointestinal stromal tumor; Ki-67; PCNA; Survivin

CLC Number: 

  • R735.2
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