Abstract:

Objective   To observe the repair effect and the degradation and absorption of the bletilla glucomannan/nacre powder composites in application of the rabbit alveolar bone’s local defect. Methods   60 rabbits were divided into 3 groups. GroupⅠ: defect was filled with bletilla glucomannan / nacre powder composites; Group Ⅱ: defect was filled with nacre powder; Group Ⅲ: defect was not filled with any implants. The effects were observed by imaging, bone mineral density(BMD), gross anatomy, histological, and alkaline phosphatase(ALP) at 1,4,8,12 weeks after surgery. Results   The nacre powder and bletilla glucomannan had a good biocompatibility. Implant material of the three groups had an entirely degradation at 12 weeks after surgery. Group Ⅰ had a better osteogenesis ability than group Ⅱ and Ⅲ. The BMD(0.411±0.0188)g·cm-2of group Ⅰ was greater than that of group Ⅱ and the BMD of group II was greater than that of group Ⅲ at 12 weeks after surgery(P＜0.05). At the same postoperative time points, the ALP activity of the group Ⅰwas significantly greater than that of group Ⅱ and Ⅲ. Conclusion   Chinese medicine bletilla glucomannan/pearl powder composites can repair partial alveolar bone defect quickly, and open up a new direction for Chinese medicine treatment of alveolar bone defect.

Key words: Alveolar bone defect; Graft material; Biocompatible material; Bletilla glucomannan; Nano-pearl powder